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Predicting Cardiovascular Stent Complications Using Self‐Reporting Biosensors for Noninvasive Detection of Disease

Self‐reporting implantable medical devices are the future of cardiovascular healthcare. Cardiovascular complications such as blocked arteries that lead to the majority of heart attacks and strokes are frequently treated with inert metal stents that reopen affected vessels. Stents frequently re‐block...

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Detalles Bibliográficos
Autores principales: Hoare, Daniel, Tsiamis, Andreas, Marland, Jamie R. K., Czyzewski, Jakub, Kirimi, Mahmut T., Holsgrove, Michael, Russell, Ewan, Neale, Steven L., Mirzai, Nosrat, Mitra, Srinjoy, Mercer, John R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9130883/
https://www.ncbi.nlm.nih.gov/pubmed/35322587
http://dx.doi.org/10.1002/advs.202105285
Descripción
Sumario:Self‐reporting implantable medical devices are the future of cardiovascular healthcare. Cardiovascular complications such as blocked arteries that lead to the majority of heart attacks and strokes are frequently treated with inert metal stents that reopen affected vessels. Stents frequently re‐block after deployment due to a wound response called in‐stent restenosis (ISR). Herein, an implantable miniaturized sensor and telemetry system are developed that can detect this process, discern the different cell types associated with ISR, distinguish sub plaque components as demonstrated with ex vivo samples, and differentiate blood from blood clot, all on a silicon substrate making it suitable for integration onto a vascular stent. This work shows that microfabricated sensors can provide clinically relevant information in settings closer to physiological conditions than previous work with cultured cells.