Development of Neutralization Breadth against Diverse HIV‐1 by Increasing Ab–Ag Interface on V2

Understanding maturation pathways of broadly neutralizing antibodies (bnAbs) against HIV‐1 can be highly informative for HIV‐1 vaccine development. A lineage of J038 bnAbs is now obtained from a long‐term SHIV‐infected macaque. J038 neutralizes 54% of global circulating HIV‐1 strains. Its binding in...

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Detalles Bibliográficos
Autores principales: Gao, Nan, Gai, Yanxin, Meng, Lina, Wang, Chu, Wang, Wei, Li, Xiaojun, Gu, Tiejun, Louder, Mark K., Doria‐Rose, Nicole A., Wiehe, Kevin, Nazzari, Alexandra F., Olia, Adam S., Gorman, Jason, Rawi, Reda, Wu, Wenmin, Smith, Clayton, Khant, Htet, de Val, Natalia, Yu, Bin, Luo, Junhong, Niu, Haitao, Tsybovsky, Yaroslav, Liao, Huaxin, Kepler, Thomas B., Kwong, Peter D., Mascola, John R., Qin, Chuan, Zhou, Tongqing, Yu, Xianghui, Gao, Feng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9130890/
https://www.ncbi.nlm.nih.gov/pubmed/35319830
http://dx.doi.org/10.1002/advs.202200063

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