A Single Dose of Oral Sucrose Is Enough to Control Pain During Venipuncture: A Randomized Controlled Trial

Sucrose is effective in reducing pain during minor procedures in neonates. We evaluated whether a second dose of sucrose was more effective than a single dose during venipuncture. We performed a randomised, double-blind, controlled trial at the NICU of Padua Hospital (August 2016-October 2017). We r...

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Autores principales: Cavicchiolo, Maria Elena, Daverio, Marco, Battajon, Nadia, Frigo, Anna Chiara, Lago, Paola
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Pain Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9131008/
https://www.ncbi.nlm.nih.gov/pubmed/35634454
http://dx.doi.org/10.3389/fpain.2022.888076
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author Cavicchiolo, Maria Elena
Daverio, Marco
Battajon, Nadia
Frigo, Anna Chiara
Lago, Paola
author_facet Cavicchiolo, Maria Elena
Daverio, Marco
Battajon, Nadia
Frigo, Anna Chiara
Lago, Paola
author_sort Cavicchiolo, Maria Elena
collection PubMed
description Sucrose is effective in reducing pain during minor procedures in neonates. We evaluated whether a second dose of sucrose was more effective than a single dose during venipuncture. We performed a randomised, double-blind, controlled trial at the NICU of Padua Hospital (August 2016-October 2017). We randomised 72 preterm infants undergoing venipuncture for routine test to a control group, which received a single standard dose of sucrose 2′ before the procedure and a placebo 30″ after the venipuncture, and an experimental group in which they received two doses of 24% sucrose 2′ before and 30″ after the venipuncture. No difference in pain perception was found between the groups at 30″, 60″ and 120″. In conclusion, we do not recommend a second dose of sucrose during venipuncture in prematures.
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spelling pubmed-91310082022-05-26 A Single Dose of Oral Sucrose Is Enough to Control Pain During Venipuncture: A Randomized Controlled Trial Cavicchiolo, Maria Elena Daverio, Marco Battajon, Nadia Frigo, Anna Chiara Lago, Paola Front Pain Res (Lausanne) Pain Research Sucrose is effective in reducing pain during minor procedures in neonates. We evaluated whether a second dose of sucrose was more effective than a single dose during venipuncture. We performed a randomised, double-blind, controlled trial at the NICU of Padua Hospital (August 2016-October 2017). We randomised 72 preterm infants undergoing venipuncture for routine test to a control group, which received a single standard dose of sucrose 2′ before the procedure and a placebo 30″ after the venipuncture, and an experimental group in which they received two doses of 24% sucrose 2′ before and 30″ after the venipuncture. No difference in pain perception was found between the groups at 30″, 60″ and 120″. In conclusion, we do not recommend a second dose of sucrose during venipuncture in prematures. Frontiers Media S.A. 2022-05-11 /pmc/articles/PMC9131008/ /pubmed/35634454 http://dx.doi.org/10.3389/fpain.2022.888076 Text en Copyright © 2022 Cavicchiolo, Daverio, Battajon, Frigo and Lago. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pain Research
Cavicchiolo, Maria Elena
Daverio, Marco
Battajon, Nadia
Frigo, Anna Chiara
Lago, Paola
A Single Dose of Oral Sucrose Is Enough to Control Pain During Venipuncture: A Randomized Controlled Trial
title A Single Dose of Oral Sucrose Is Enough to Control Pain During Venipuncture: A Randomized Controlled Trial
title_full A Single Dose of Oral Sucrose Is Enough to Control Pain During Venipuncture: A Randomized Controlled Trial
title_fullStr A Single Dose of Oral Sucrose Is Enough to Control Pain During Venipuncture: A Randomized Controlled Trial
title_full_unstemmed A Single Dose of Oral Sucrose Is Enough to Control Pain During Venipuncture: A Randomized Controlled Trial
title_short A Single Dose of Oral Sucrose Is Enough to Control Pain During Venipuncture: A Randomized Controlled Trial
title_sort single dose of oral sucrose is enough to control pain during venipuncture: a randomized controlled trial
topic Pain Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9131008/
https://www.ncbi.nlm.nih.gov/pubmed/35634454
http://dx.doi.org/10.3389/fpain.2022.888076
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