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Obesity and Impaired Metabolic Health Increase Risk of COVID-19-Related Mortality in Young and Middle-Aged Adults to the Level Observed in Older People: The LEOSS Registry
Advanced age, followed by male sex, by far poses the greatest risk for severe COVID-19. An unresolved question is the extent to which modifiable comorbidities increase the risk of COVID-19-related mortality among younger patients, in whom COVID-19-related hospitalization strongly increased in 2021....
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9131026/ https://www.ncbi.nlm.nih.gov/pubmed/35646955 http://dx.doi.org/10.3389/fmed.2022.875430 |
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author | Stefan, Norbert Sippel, Katrin Heni, Martin Fritsche, Andreas Wagner, Robert Jakob, Carolin E. M. Preißl, Hubert von Werder, Alexander Khodamoradi, Yascha Borgmann, Stefan Rüthrich, Maria Madeleine Hanses, Frank Haselberger, Martina Piepel, Christiane Hower, Martin vom Dahl, Jürgen Wille, Kai Römmele, Christoph Vehreschild, Janne Stecher, Melanie Solimena, Michele Roden, Michael Schürmann, Annette Gallwitz, Baptist Hrabe de Angelis, Martin Ludwig, David S. Schulze, Matthias B. Jensen, Bjoern Erik Ole Birkenfeld, Andreas L. |
author_facet | Stefan, Norbert Sippel, Katrin Heni, Martin Fritsche, Andreas Wagner, Robert Jakob, Carolin E. M. Preißl, Hubert von Werder, Alexander Khodamoradi, Yascha Borgmann, Stefan Rüthrich, Maria Madeleine Hanses, Frank Haselberger, Martina Piepel, Christiane Hower, Martin vom Dahl, Jürgen Wille, Kai Römmele, Christoph Vehreschild, Janne Stecher, Melanie Solimena, Michele Roden, Michael Schürmann, Annette Gallwitz, Baptist Hrabe de Angelis, Martin Ludwig, David S. Schulze, Matthias B. Jensen, Bjoern Erik Ole Birkenfeld, Andreas L. |
author_sort | Stefan, Norbert |
collection | PubMed |
description | Advanced age, followed by male sex, by far poses the greatest risk for severe COVID-19. An unresolved question is the extent to which modifiable comorbidities increase the risk of COVID-19-related mortality among younger patients, in whom COVID-19-related hospitalization strongly increased in 2021. A total of 3,163 patients with SARS-COV-2 diagnosis in the Lean European Open Survey on SARS-CoV-2-Infected Patients (LEOSS) cohort were studied. LEOSS is a European non-interventional multi-center cohort study established in March 2020 to investigate the epidemiology and clinical course of SARS-CoV-2 infection. Data from hospitalized patients and those who received ambulatory care, with a positive SARS-CoV-2 test, were included in the study. An additive effect of obesity, diabetes and hypertension on the risk of mortality was observed, which was particularly strong in young and middle-aged patients. Compared to young and middle-aged (18–55 years) patients without obesity, diabetes and hypertension (non-obese and metabolically healthy; n = 593), young and middle-aged adult patients with all three risk parameters (obese and metabolically unhealthy; n = 31) had a similar adjusted increased risk of mortality [OR 7.42 (95% CI 1.55–27.3)] as older (56–75 years) non-obese and metabolically healthy patients [n = 339; OR 8.21 (95% CI 4.10–18.3)]. Furthermore, increased CRP levels explained part of the elevated risk of COVID-19-related mortality with age, specifically in the absence of obesity and impaired metabolic health. In conclusion, the modifiable risk factors obesity, diabetes and hypertension increase the risk of COVID-19-related mortality in young and middle-aged patients to the level of risk observed in advanced age. |
format | Online Article Text |
id | pubmed-9131026 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-91310262022-05-26 Obesity and Impaired Metabolic Health Increase Risk of COVID-19-Related Mortality in Young and Middle-Aged Adults to the Level Observed in Older People: The LEOSS Registry Stefan, Norbert Sippel, Katrin Heni, Martin Fritsche, Andreas Wagner, Robert Jakob, Carolin E. M. Preißl, Hubert von Werder, Alexander Khodamoradi, Yascha Borgmann, Stefan Rüthrich, Maria Madeleine Hanses, Frank Haselberger, Martina Piepel, Christiane Hower, Martin vom Dahl, Jürgen Wille, Kai Römmele, Christoph Vehreschild, Janne Stecher, Melanie Solimena, Michele Roden, Michael Schürmann, Annette Gallwitz, Baptist Hrabe de Angelis, Martin Ludwig, David S. Schulze, Matthias B. Jensen, Bjoern Erik Ole Birkenfeld, Andreas L. Front Med (Lausanne) Medicine Advanced age, followed by male sex, by far poses the greatest risk for severe COVID-19. An unresolved question is the extent to which modifiable comorbidities increase the risk of COVID-19-related mortality among younger patients, in whom COVID-19-related hospitalization strongly increased in 2021. A total of 3,163 patients with SARS-COV-2 diagnosis in the Lean European Open Survey on SARS-CoV-2-Infected Patients (LEOSS) cohort were studied. LEOSS is a European non-interventional multi-center cohort study established in March 2020 to investigate the epidemiology and clinical course of SARS-CoV-2 infection. Data from hospitalized patients and those who received ambulatory care, with a positive SARS-CoV-2 test, were included in the study. An additive effect of obesity, diabetes and hypertension on the risk of mortality was observed, which was particularly strong in young and middle-aged patients. Compared to young and middle-aged (18–55 years) patients without obesity, diabetes and hypertension (non-obese and metabolically healthy; n = 593), young and middle-aged adult patients with all three risk parameters (obese and metabolically unhealthy; n = 31) had a similar adjusted increased risk of mortality [OR 7.42 (95% CI 1.55–27.3)] as older (56–75 years) non-obese and metabolically healthy patients [n = 339; OR 8.21 (95% CI 4.10–18.3)]. Furthermore, increased CRP levels explained part of the elevated risk of COVID-19-related mortality with age, specifically in the absence of obesity and impaired metabolic health. In conclusion, the modifiable risk factors obesity, diabetes and hypertension increase the risk of COVID-19-related mortality in young and middle-aged patients to the level of risk observed in advanced age. Frontiers Media S.A. 2022-05-11 /pmc/articles/PMC9131026/ /pubmed/35646955 http://dx.doi.org/10.3389/fmed.2022.875430 Text en Copyright © 2022 Stefan, Sippel, Heni, Fritsche, Wagner, Jakob, Preißl, von Werder, Khodamoradi, Borgmann, Rüthrich, Hanses, Haselberger, Piepel, Hower, vom Dahl, Wille, Römmele, Vehreschild, Stecher, Solimena, Roden, Schürmann, Gallwitz, Hrabe de Angelis, Ludwig, Schulze, Jensen and Birkenfeld. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Medicine Stefan, Norbert Sippel, Katrin Heni, Martin Fritsche, Andreas Wagner, Robert Jakob, Carolin E. M. Preißl, Hubert von Werder, Alexander Khodamoradi, Yascha Borgmann, Stefan Rüthrich, Maria Madeleine Hanses, Frank Haselberger, Martina Piepel, Christiane Hower, Martin vom Dahl, Jürgen Wille, Kai Römmele, Christoph Vehreschild, Janne Stecher, Melanie Solimena, Michele Roden, Michael Schürmann, Annette Gallwitz, Baptist Hrabe de Angelis, Martin Ludwig, David S. Schulze, Matthias B. Jensen, Bjoern Erik Ole Birkenfeld, Andreas L. Obesity and Impaired Metabolic Health Increase Risk of COVID-19-Related Mortality in Young and Middle-Aged Adults to the Level Observed in Older People: The LEOSS Registry |
title | Obesity and Impaired Metabolic Health Increase Risk of COVID-19-Related Mortality in Young and Middle-Aged Adults to the Level Observed in Older People: The LEOSS Registry |
title_full | Obesity and Impaired Metabolic Health Increase Risk of COVID-19-Related Mortality in Young and Middle-Aged Adults to the Level Observed in Older People: The LEOSS Registry |
title_fullStr | Obesity and Impaired Metabolic Health Increase Risk of COVID-19-Related Mortality in Young and Middle-Aged Adults to the Level Observed in Older People: The LEOSS Registry |
title_full_unstemmed | Obesity and Impaired Metabolic Health Increase Risk of COVID-19-Related Mortality in Young and Middle-Aged Adults to the Level Observed in Older People: The LEOSS Registry |
title_short | Obesity and Impaired Metabolic Health Increase Risk of COVID-19-Related Mortality in Young and Middle-Aged Adults to the Level Observed in Older People: The LEOSS Registry |
title_sort | obesity and impaired metabolic health increase risk of covid-19-related mortality in young and middle-aged adults to the level observed in older people: the leoss registry |
topic | Medicine |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9131026/ https://www.ncbi.nlm.nih.gov/pubmed/35646955 http://dx.doi.org/10.3389/fmed.2022.875430 |
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