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Obesity and Impaired Metabolic Health Increase Risk of COVID-19-Related Mortality in Young and Middle-Aged Adults to the Level Observed in Older People: The LEOSS Registry

Advanced age, followed by male sex, by far poses the greatest risk for severe COVID-19. An unresolved question is the extent to which modifiable comorbidities increase the risk of COVID-19-related mortality among younger patients, in whom COVID-19-related hospitalization strongly increased in 2021....

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Autores principales: Stefan, Norbert, Sippel, Katrin, Heni, Martin, Fritsche, Andreas, Wagner, Robert, Jakob, Carolin E. M., Preißl, Hubert, von Werder, Alexander, Khodamoradi, Yascha, Borgmann, Stefan, Rüthrich, Maria Madeleine, Hanses, Frank, Haselberger, Martina, Piepel, Christiane, Hower, Martin, vom Dahl, Jürgen, Wille, Kai, Römmele, Christoph, Vehreschild, Janne, Stecher, Melanie, Solimena, Michele, Roden, Michael, Schürmann, Annette, Gallwitz, Baptist, Hrabe de Angelis, Martin, Ludwig, David S., Schulze, Matthias B., Jensen, Bjoern Erik Ole, Birkenfeld, Andreas L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9131026/
https://www.ncbi.nlm.nih.gov/pubmed/35646955
http://dx.doi.org/10.3389/fmed.2022.875430
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author Stefan, Norbert
Sippel, Katrin
Heni, Martin
Fritsche, Andreas
Wagner, Robert
Jakob, Carolin E. M.
Preißl, Hubert
von Werder, Alexander
Khodamoradi, Yascha
Borgmann, Stefan
Rüthrich, Maria Madeleine
Hanses, Frank
Haselberger, Martina
Piepel, Christiane
Hower, Martin
vom Dahl, Jürgen
Wille, Kai
Römmele, Christoph
Vehreschild, Janne
Stecher, Melanie
Solimena, Michele
Roden, Michael
Schürmann, Annette
Gallwitz, Baptist
Hrabe de Angelis, Martin
Ludwig, David S.
Schulze, Matthias B.
Jensen, Bjoern Erik Ole
Birkenfeld, Andreas L.
author_facet Stefan, Norbert
Sippel, Katrin
Heni, Martin
Fritsche, Andreas
Wagner, Robert
Jakob, Carolin E. M.
Preißl, Hubert
von Werder, Alexander
Khodamoradi, Yascha
Borgmann, Stefan
Rüthrich, Maria Madeleine
Hanses, Frank
Haselberger, Martina
Piepel, Christiane
Hower, Martin
vom Dahl, Jürgen
Wille, Kai
Römmele, Christoph
Vehreschild, Janne
Stecher, Melanie
Solimena, Michele
Roden, Michael
Schürmann, Annette
Gallwitz, Baptist
Hrabe de Angelis, Martin
Ludwig, David S.
Schulze, Matthias B.
Jensen, Bjoern Erik Ole
Birkenfeld, Andreas L.
author_sort Stefan, Norbert
collection PubMed
description Advanced age, followed by male sex, by far poses the greatest risk for severe COVID-19. An unresolved question is the extent to which modifiable comorbidities increase the risk of COVID-19-related mortality among younger patients, in whom COVID-19-related hospitalization strongly increased in 2021. A total of 3,163 patients with SARS-COV-2 diagnosis in the Lean European Open Survey on SARS-CoV-2-Infected Patients (LEOSS) cohort were studied. LEOSS is a European non-interventional multi-center cohort study established in March 2020 to investigate the epidemiology and clinical course of SARS-CoV-2 infection. Data from hospitalized patients and those who received ambulatory care, with a positive SARS-CoV-2 test, were included in the study. An additive effect of obesity, diabetes and hypertension on the risk of mortality was observed, which was particularly strong in young and middle-aged patients. Compared to young and middle-aged (18–55 years) patients without obesity, diabetes and hypertension (non-obese and metabolically healthy; n = 593), young and middle-aged adult patients with all three risk parameters (obese and metabolically unhealthy; n = 31) had a similar adjusted increased risk of mortality [OR 7.42 (95% CI 1.55–27.3)] as older (56–75 years) non-obese and metabolically healthy patients [n = 339; OR 8.21 (95% CI 4.10–18.3)]. Furthermore, increased CRP levels explained part of the elevated risk of COVID-19-related mortality with age, specifically in the absence of obesity and impaired metabolic health. In conclusion, the modifiable risk factors obesity, diabetes and hypertension increase the risk of COVID-19-related mortality in young and middle-aged patients to the level of risk observed in advanced age.
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spelling pubmed-91310262022-05-26 Obesity and Impaired Metabolic Health Increase Risk of COVID-19-Related Mortality in Young and Middle-Aged Adults to the Level Observed in Older People: The LEOSS Registry Stefan, Norbert Sippel, Katrin Heni, Martin Fritsche, Andreas Wagner, Robert Jakob, Carolin E. M. Preißl, Hubert von Werder, Alexander Khodamoradi, Yascha Borgmann, Stefan Rüthrich, Maria Madeleine Hanses, Frank Haselberger, Martina Piepel, Christiane Hower, Martin vom Dahl, Jürgen Wille, Kai Römmele, Christoph Vehreschild, Janne Stecher, Melanie Solimena, Michele Roden, Michael Schürmann, Annette Gallwitz, Baptist Hrabe de Angelis, Martin Ludwig, David S. Schulze, Matthias B. Jensen, Bjoern Erik Ole Birkenfeld, Andreas L. Front Med (Lausanne) Medicine Advanced age, followed by male sex, by far poses the greatest risk for severe COVID-19. An unresolved question is the extent to which modifiable comorbidities increase the risk of COVID-19-related mortality among younger patients, in whom COVID-19-related hospitalization strongly increased in 2021. A total of 3,163 patients with SARS-COV-2 diagnosis in the Lean European Open Survey on SARS-CoV-2-Infected Patients (LEOSS) cohort were studied. LEOSS is a European non-interventional multi-center cohort study established in March 2020 to investigate the epidemiology and clinical course of SARS-CoV-2 infection. Data from hospitalized patients and those who received ambulatory care, with a positive SARS-CoV-2 test, were included in the study. An additive effect of obesity, diabetes and hypertension on the risk of mortality was observed, which was particularly strong in young and middle-aged patients. Compared to young and middle-aged (18–55 years) patients without obesity, diabetes and hypertension (non-obese and metabolically healthy; n = 593), young and middle-aged adult patients with all three risk parameters (obese and metabolically unhealthy; n = 31) had a similar adjusted increased risk of mortality [OR 7.42 (95% CI 1.55–27.3)] as older (56–75 years) non-obese and metabolically healthy patients [n = 339; OR 8.21 (95% CI 4.10–18.3)]. Furthermore, increased CRP levels explained part of the elevated risk of COVID-19-related mortality with age, specifically in the absence of obesity and impaired metabolic health. In conclusion, the modifiable risk factors obesity, diabetes and hypertension increase the risk of COVID-19-related mortality in young and middle-aged patients to the level of risk observed in advanced age. Frontiers Media S.A. 2022-05-11 /pmc/articles/PMC9131026/ /pubmed/35646955 http://dx.doi.org/10.3389/fmed.2022.875430 Text en Copyright © 2022 Stefan, Sippel, Heni, Fritsche, Wagner, Jakob, Preißl, von Werder, Khodamoradi, Borgmann, Rüthrich, Hanses, Haselberger, Piepel, Hower, vom Dahl, Wille, Römmele, Vehreschild, Stecher, Solimena, Roden, Schürmann, Gallwitz, Hrabe de Angelis, Ludwig, Schulze, Jensen and Birkenfeld. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Medicine
Stefan, Norbert
Sippel, Katrin
Heni, Martin
Fritsche, Andreas
Wagner, Robert
Jakob, Carolin E. M.
Preißl, Hubert
von Werder, Alexander
Khodamoradi, Yascha
Borgmann, Stefan
Rüthrich, Maria Madeleine
Hanses, Frank
Haselberger, Martina
Piepel, Christiane
Hower, Martin
vom Dahl, Jürgen
Wille, Kai
Römmele, Christoph
Vehreschild, Janne
Stecher, Melanie
Solimena, Michele
Roden, Michael
Schürmann, Annette
Gallwitz, Baptist
Hrabe de Angelis, Martin
Ludwig, David S.
Schulze, Matthias B.
Jensen, Bjoern Erik Ole
Birkenfeld, Andreas L.
Obesity and Impaired Metabolic Health Increase Risk of COVID-19-Related Mortality in Young and Middle-Aged Adults to the Level Observed in Older People: The LEOSS Registry
title Obesity and Impaired Metabolic Health Increase Risk of COVID-19-Related Mortality in Young and Middle-Aged Adults to the Level Observed in Older People: The LEOSS Registry
title_full Obesity and Impaired Metabolic Health Increase Risk of COVID-19-Related Mortality in Young and Middle-Aged Adults to the Level Observed in Older People: The LEOSS Registry
title_fullStr Obesity and Impaired Metabolic Health Increase Risk of COVID-19-Related Mortality in Young and Middle-Aged Adults to the Level Observed in Older People: The LEOSS Registry
title_full_unstemmed Obesity and Impaired Metabolic Health Increase Risk of COVID-19-Related Mortality in Young and Middle-Aged Adults to the Level Observed in Older People: The LEOSS Registry
title_short Obesity and Impaired Metabolic Health Increase Risk of COVID-19-Related Mortality in Young and Middle-Aged Adults to the Level Observed in Older People: The LEOSS Registry
title_sort obesity and impaired metabolic health increase risk of covid-19-related mortality in young and middle-aged adults to the level observed in older people: the leoss registry
topic Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9131026/
https://www.ncbi.nlm.nih.gov/pubmed/35646955
http://dx.doi.org/10.3389/fmed.2022.875430
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