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Sortilin enhances secretion of apolipoprotein(a) through effects on apolipoprotein B secretion and promotes uptake of lipoprotein(a)

Elevated plasma lipoprotein(a) (Lp(a)) is an independent, causal risk factor for atherosclerotic cardiovascular disease and calcific aortic valve stenosis. Lp(a) is formed in or on hepatocytes from successive noncovalent and covalent interactions between apo(a) and apoB, although the subcellular loc...

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Detalles Bibliográficos
Autores principales:	Clark, Justin R., Gemin, Matthew, Youssef, Amer, Marcovina, Santica M., Prat, Annik, Seidah, Nabil G., Hegele, Robert A., Boffa, Michael B., Koschinsky, Marlys L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9131257/ https://www.ncbi.nlm.nih.gov/pubmed/35469919 http://dx.doi.org/10.1016/j.jlr.2022.100216

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