Single‐Cell RNA‐seq Reveals a Developmental Hierarchy Super‐Imposed Over Subclonal Evolution in the Cellular Ecosystem of Prostate Cancer

Prostate cancer (PCa) is a complex disease. An ongoing accumulation of mutations results in increased genetic diversity, with the tumor acquiring distinct subclones. However, non‐genetic intra‐tumoral heterogeneity, the cellular differentiation state and the interplay between subclonal evolution and...

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Detalles Bibliográficos
Autores principales: Ge, Guangzhe, Han, Yang, Zhang, Jianye, Li, Xinxin, Liu, Xiaodan, Gong, Yanqing, Lei, Zhentao, Wang, Jie, Zhu, Weijie, Xu, Yangyang, Peng, Yiji, Deng, Jianhua, Zhang, Bao, Li, Xuesong, Zhou, Liqun, He, Huiying, Ci, Weimin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9131431/
https://www.ncbi.nlm.nih.gov/pubmed/35322584
http://dx.doi.org/10.1002/advs.202105530

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