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Asperosaponin VI ameliorates the CMS-induced depressive-like behaviors by inducing a neuroprotective microglial phenotype in hippocampus via PPAR-γ pathway

BACKGROUND: The natural compound asperosaponin VI has shown potential as an antidepressant, but how it works is unclear. Here, we explored its effects on mice exposed to chronic mild stress (CMS) and the underlying molecular pathways. METHODS: Mice were exposed to CMS for 3 weeks followed by asperos...

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Detalles Bibliográficos
Autores principales:	Jiang, Xue, Yi, Saini, Liu, Qin, Su, Dapeng, Li, Liangyuan, Xiao, Chenghong, Zhang, Jinqiang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2022
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9131532/ https://www.ncbi.nlm.nih.gov/pubmed/35610721 http://dx.doi.org/10.1186/s12974-022-02478-y

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