Cargando…

Asperosaponin VI ameliorates the CMS-induced depressive-like behaviors by inducing a neuroprotective microglial phenotype in hippocampus via PPAR-γ pathway

BACKGROUND: The natural compound asperosaponin VI has shown potential as an antidepressant, but how it works is unclear. Here, we explored its effects on mice exposed to chronic mild stress (CMS) and the underlying molecular pathways. METHODS: Mice were exposed to CMS for 3 weeks followed by asperos...

Descripción completa

Detalles Bibliográficos
Autores principales:	Jiang, Xue, Yi, Saini, Liu, Qin, Su, Dapeng, Li, Liangyuan, Xiao, Chenghong, Zhang, Jinqiang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2022
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9131532/ https://www.ncbi.nlm.nih.gov/pubmed/35610721 http://dx.doi.org/10.1186/s12974-022-02478-y

Ejemplares similares

Asperosaponin VI inhibits LPS-induced inflammatory response by activating PPAR-γ pathway in primary microglia
por: Zhang, Jinqiang, et al.
Publicado: (2020)

Transcriptome analysis reveals that jasmonic acid biosynthesis and signaling is associated with the biosynthesis of asperosaponin VI in Dipsacus asperoides
por: Xu, Jiao, et al.
Publicado: (2022)

Therapeutic effects of asperosaponin VI in rabbit tendon disease
por: Wang, Kun, et al.
Publicado: (2022)

Asperosaponin VI Injection Enhances Orthodontic Tooth Movement in Rats
por: Ma, Dan, et al.
Publicado: (2020)

Hypoxia inducible factor-1α mediates the mechanism of the Hedgehog pathway in tendinopathy repair by Asperosaponin VI
por: Wang, Kun, et al.
Publicado: (2022)

Asperosaponin VI stimulates osteogenic differentiation of rat adipose-derived stem cells
por: Ding, Xingpo, et al.
Publicado: (2019)

Synergy effects of Asperosaponin VI and bioactive factor BMP-2 on osteogenesis and anti-osteoclastogenesis
por: Chen, Fangping, et al.
Publicado: (2021)

Asperosaponin VI induces osteogenic differentiation of human umbilical cord mesenchymal stem cells via the estrogen signaling pathway
por: Niu, Junting, et al.
Publicado: (2022)

Research on the Mechanism of Asperosaponin VI for Treating Recurrent Spontaneous Abortion by Bioinformatics Analysis and Experimental Validation
por: Xia, Bo, et al.
Publicado: (2022)

Akebia saponin D acts via the PPAR‐gamma pathway to reprogramme a pro‐neurogenic microglia that can restore hippocampal neurogenesis in mice exposed to chronic mild stress
por: Zhang, Jinqiang, et al.
Publicado: (2023)

The PPAR-γ agonist pioglitazone modulates inflammation and induces neuroprotection in parkinsonian monkeys
por: Swanson, Christine R, et al.
Publicado: (2011)

In the presence of TGF-β1, Asperosaponin VI promotes human mesenchymal stem cell differentiation into nucleus pulposus like- cells
por: Niu, Yong-tao, et al.
Publicado: (2021)

Akebia saponin D protects hippocampal neurogenesis from microglia-mediated inflammation and ameliorates depressive-like behaviors and cognitive impairment in mice through the PI3K-Akt pathway
por: Liu, Qin, et al.
Publicado: (2022)

Geniposide ameliorated sepsis-induced acute kidney injury by activating PPARγ
por: Liu, Jinhong, et al.
Publicado: (2020)

Asperosaponin VI promotes bone marrow stromal cell osteogenic differentiation through the PI3K/AKT signaling pathway in an osteoporosis model
por: Ke, Ke, et al.
Publicado: (2016)

The antidepressant-like effects of pioglitazone in a chronic mild stress mouse model are associated with PPARγ-mediated alteration of microglial activation phenotypes
por: Zhao, Qiuying, et al.
Publicado: (2016)

Mouse Astrocytes Promote Microglial Ramification by Releasing TGF-β and Forming Glial Fibers
por: Zhang, Jinqiang, et al.
Publicado: (2020)

Abscisic acid interplays with PPARγ receptors and ameliorates diabetes-induced cognitive deficits in rats
por: Kooshki, Razieh, et al.
Publicado: (2021)

PPAR-γ, Microglial Cells, and Ocular Inflammation: New Venues for Potential Therapeutic Approaches
por: Malchiodi-Albedi, Fiorella, et al.
Publicado: (2008)

Neuronal seipin knockout facilitates Aβ-induced neuroinflammation and neurotoxicity via reduction of PPARγ in hippocampus of mouse
por: Qian, Yun, et al.
Publicado: (2016)

Peroxisome Proliferator Activator Receptor (PPAR)-γ Ligand, but Not PPAR-α, Ameliorates Cyclophosphamide-Induced Oxidative Stress and Inflammation in Rat Liver
por: El-Sheikh, Azza A. K., et al.
Publicado: (2014)

Comparative Gene Expression Profiles Induced by PPARγ and PPARα/γ Agonists in Human Hepatocytes
por: Rogue, Alexandra, et al.
Publicado: (2011)

MDG-1, a Potential Regulator of PPARα and PPARγ, Ameliorates Dyslipidemia in Mice
por: Wang, Xu, et al.
Publicado: (2017)

PPARγ Agonists Improve Survival and Neurocognitive Outcomes in Experimental Cerebral Malaria and Induce Neuroprotective Pathways in Human Malaria
por: Serghides, Lena, et al.
Publicado: (2014)

Microglial Ultrastructure in the Hippocampus of a Lipopolysaccharide-Induced Sickness Mouse Model
por: Savage, Julie C., et al.
Publicado: (2019)

Dietary component isorhamnetin is a PPARγ antagonist and ameliorates metabolic disorders induced by diet or leptin deficiency
por: Zhang, Yu, et al.
Publicado: (2016)

Inhibition of PPARγ by bisphenol A diglycidyl ether ameliorates dexamethasone-induced osteoporosis in a mouse model
por: Wang, Yaoqing, et al.
Publicado: (2019)

The role of PPARγ in childhood obesity-induced fractures
por: McCann, Matthew R., et al.
Publicado: (2019)

PPARγ Regulates Triclosan Induced Placental Dysfunction
por: Li, Jing, et al.
Publicado: (2021)

PPARγ and PPARα synergize to induce robust browning of white fat in vivo
por: Kroon, Tobias, et al.
Publicado: (2020)

Dexmedetomidine facilitates the expression of nNOS in the hippocampus to alleviate surgery-induced neuroinflammation and cognitive dysfunction in aged rats
por: Suo, Liangyuan, et al.
Publicado: (2021)

Molecular evidence for the involvement of PPAR-δ and PPAR-γ in anti-inflammatory and neuroprotective activities of palmitoylethanolamide after spinal cord trauma
por: Paterniti, Irene, et al.
Publicado: (2013)

Divergent Mechanisms for PPARγ Agonism in Ameliorating Aging-Related Versus Cranial Irradiation-Induced Context Discrimination Deficits
por: Cortez, Ibdanelo, et al.
Publicado: (2019)

Ginsenoside Rb1 induces a pro-neurogenic microglial phenotype via PPARγ activation in male mice exposed to chronic mild stress
por: Zhang, Lijuan, et al.
Publicado: (2021)

Neuroprotective Properties of a Novel Non-Thiazoledinedione Partial PPAR-γ Agonist against MPTP
por: Swanson, Christine R., et al.
Publicado: (2013)

Neuroprotective Potential of Gentongping in Rat Model of Cervical Spondylotic Radiculopathy Targeting PPAR-γ Pathway
por: Sun, Wen, et al.
Publicado: (2017)

Post-Treatment with Amorfrutin B Evokes PPARγ-Mediated Neuroprotection against Hypoxia and Ischemia
por: Wnuk, Agnieszka, et al.
Publicado: (2021)

Chronic skin ultraviolet irradiation induces transcriptomic changes associated with microglial dysfunction in the hippocampus
por: Yoon, Kyeong-No, et al.
Publicado: (2022)

Preliminary analysis of hippocampus synaptic apoptosis and microglial phagocytosis induced by severe restraint stress
por: Enomoto, Shingo, et al.
Publicado: (2022)

Genome-Wide Transcriptional Excavation of Dipsacus asperoides Unmasked both Cryptic Asperosaponin Biosynthetic Genes and SSR Markers
por: Wang, Jian-ying, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_scjpqsskfkgn7r3fqgbbbf67t1