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Perianesthetic mortality in English Bulldogs: a retrospective analysis in 2010 – 2017
BACKGROUND: Many veterinarians consider English Bulldogs to have a greater perianesthetic mortality risk. The aims of this study were to 1) determine total and anesthesia-related, perianesthetic mortality (PAM) rates in English Bulldogs (EB), 2) identify potential risk factors associated with mortal...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9131676/ https://www.ncbi.nlm.nih.gov/pubmed/35614460 http://dx.doi.org/10.1186/s12917-022-03301-9 |
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author | Oda, Ayako Wang, Wen Hui Hampton, Amanda K. Robertson, James B. Posner, Lysa P. |
author_facet | Oda, Ayako Wang, Wen Hui Hampton, Amanda K. Robertson, James B. Posner, Lysa P. |
author_sort | Oda, Ayako |
collection | PubMed |
description | BACKGROUND: Many veterinarians consider English Bulldogs to have a greater perianesthetic mortality risk. The aims of this study were to 1) determine total and anesthesia-related, perianesthetic mortality (PAM) rates in English Bulldogs (EB), 2) identify potential risk factors associated with mortality in EB, and 3) determine the difference in the perianesthetic mortality rates between EB, other-brachycephalic breeds (OB), and non-brachycephalic breeds (NB). Records from EB that were anesthetized between 2010 and 2017, were investigated. OB and NB were enrolled to match with each EB based on a procedure and age from the study period. Data collected in EB included: age, ASA status, weight, procedure types, anesthetic and analgesic management, anesthetic duration, anesthetic recovery location, and cause of death. Age and cause of death were determined from OB and NB. Fisher’s exact test was used to compare PAM rate and age in EB, OB, and NB. Mann–Whitney U test was used to compare EB survivor and EB non-survivor. Logistic regression models were used to identify factors and odds ratio (OR) associated with PAM in EB. RESULT: Two hundred twenty nine EB, 218 OB, and 229 NB were identified. The total and anesthesia-related PAM rates in EB were 6.6 and 3.9%, respectively. EB had a greater total PAM rate compared with OB (p = 0.007). ASA status was different between survivors and non-survivors in EB (p < 0.01). Risk factors identified regardless of the cause of death were premedication with full μ opioids (OR = 0.333, p = 0.114), continuous infusion of ketamine post-operatively (OR = 13.775, p = 0.013), and acepromazine administration post-operatively (OR = 7.274, p = 0.004). The most common cause of death in EB was postoperative respiratory dysfunction (87.5%). CONCLUSION: Total and anesthesia-related mortality in EB is considerable. Most deaths in EB occurred during the postoperative period secondary to respiratory complications. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12917-022-03301-9. |
format | Online Article Text |
id | pubmed-9131676 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-91316762022-05-26 Perianesthetic mortality in English Bulldogs: a retrospective analysis in 2010 – 2017 Oda, Ayako Wang, Wen Hui Hampton, Amanda K. Robertson, James B. Posner, Lysa P. BMC Vet Res Research BACKGROUND: Many veterinarians consider English Bulldogs to have a greater perianesthetic mortality risk. The aims of this study were to 1) determine total and anesthesia-related, perianesthetic mortality (PAM) rates in English Bulldogs (EB), 2) identify potential risk factors associated with mortality in EB, and 3) determine the difference in the perianesthetic mortality rates between EB, other-brachycephalic breeds (OB), and non-brachycephalic breeds (NB). Records from EB that were anesthetized between 2010 and 2017, were investigated. OB and NB were enrolled to match with each EB based on a procedure and age from the study period. Data collected in EB included: age, ASA status, weight, procedure types, anesthetic and analgesic management, anesthetic duration, anesthetic recovery location, and cause of death. Age and cause of death were determined from OB and NB. Fisher’s exact test was used to compare PAM rate and age in EB, OB, and NB. Mann–Whitney U test was used to compare EB survivor and EB non-survivor. Logistic regression models were used to identify factors and odds ratio (OR) associated with PAM in EB. RESULT: Two hundred twenty nine EB, 218 OB, and 229 NB were identified. The total and anesthesia-related PAM rates in EB were 6.6 and 3.9%, respectively. EB had a greater total PAM rate compared with OB (p = 0.007). ASA status was different between survivors and non-survivors in EB (p < 0.01). Risk factors identified regardless of the cause of death were premedication with full μ opioids (OR = 0.333, p = 0.114), continuous infusion of ketamine post-operatively (OR = 13.775, p = 0.013), and acepromazine administration post-operatively (OR = 7.274, p = 0.004). The most common cause of death in EB was postoperative respiratory dysfunction (87.5%). CONCLUSION: Total and anesthesia-related mortality in EB is considerable. Most deaths in EB occurred during the postoperative period secondary to respiratory complications. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12917-022-03301-9. BioMed Central 2022-05-25 /pmc/articles/PMC9131676/ /pubmed/35614460 http://dx.doi.org/10.1186/s12917-022-03301-9 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Research Oda, Ayako Wang, Wen Hui Hampton, Amanda K. Robertson, James B. Posner, Lysa P. Perianesthetic mortality in English Bulldogs: a retrospective analysis in 2010 – 2017 |
title | Perianesthetic mortality in English Bulldogs: a retrospective analysis in 2010 – 2017 |
title_full | Perianesthetic mortality in English Bulldogs: a retrospective analysis in 2010 – 2017 |
title_fullStr | Perianesthetic mortality in English Bulldogs: a retrospective analysis in 2010 – 2017 |
title_full_unstemmed | Perianesthetic mortality in English Bulldogs: a retrospective analysis in 2010 – 2017 |
title_short | Perianesthetic mortality in English Bulldogs: a retrospective analysis in 2010 – 2017 |
title_sort | perianesthetic mortality in english bulldogs: a retrospective analysis in 2010 – 2017 |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9131676/ https://www.ncbi.nlm.nih.gov/pubmed/35614460 http://dx.doi.org/10.1186/s12917-022-03301-9 |
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