Inhibition of Crmp1 Phosphorylation at Ser522 Ameliorates Motor Function and Neuronal Pathology in Amyotrophic Lateral Sclerosis Model Mice

Amyotrophic lateral sclerosis (ALS) is a rapidly progressive and fatal neurodegenerative disorder that affects upper and lower motor neurons; however, its pathomechanism has not been fully elucidated. Using a comprehensive phosphoproteomic approach, we have identified elevated phosphorylation of Col...

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Detalles Bibliográficos
Autores principales: Asano, Tetsuya, Nakamura, Haruko, Kawamoto, Yuko, Tada, Mikiko, Kimura, Yayoi, Takano, Hiroshi, Yao, Ryoji, Saito, Hiroya, Ikeda, Takuya, Komiya, Hiroyasu, Kubota, Shun, Hashiguchi, Shunta, Takahashi, Keita, Kunii, Misako, Tanaka, Kenichi, Goshima, Yoshio, Nakamura, Fumio, Takeuchi, Hideyuki, Doi, Hiroshi, Tanaka, Fumiaki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Society for Neuroscience 2022
Materias:
Research Article: New Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9131721/
https://www.ncbi.nlm.nih.gov/pubmed/35523582
http://dx.doi.org/10.1523/ENEURO.0133-22.2022

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