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Updates on systemic therapy for cervical cancer
Cervical cancer is one of the most common cancers in the world both in terms of incidence and mortality, more so important in low- and middle-income countries. Surgery and radiotherapy remain the backbone of treatment for non-metastatic cervical cancer, with significant improvement in survival provi...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wolters Kluwer - Medknow
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9131767/ https://www.ncbi.nlm.nih.gov/pubmed/35295013 http://dx.doi.org/10.4103/ijmr.IJMR_4454_20 |
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author | Gopu, Paul Antony, Febin Cyriac, Sunu Karakasis, Katherine Oza, Amit M. |
author_facet | Gopu, Paul Antony, Febin Cyriac, Sunu Karakasis, Katherine Oza, Amit M. |
author_sort | Gopu, Paul |
collection | PubMed |
description | Cervical cancer is one of the most common cancers in the world both in terms of incidence and mortality, more so important in low- and middle-income countries. Surgery and radiotherapy remain the backbone of treatment for non-metastatic cervical cancer, with significant improvement in survival provided by addition of chemotherapy to radiotherapy. Survival as well as quality of life is improved by chemotherapy in metastatic disease. Platinum-based chemotherapy with/without bevacizumab is the mainstay of treatment for metastatic disease and has shown improvement in survival. The right combinations and sequence of treatment modalities and medicines are still evolving. Data regarding the molecular and genomic biology of cervical cancer have revealed multiple potential targets for treatment, and several new agents are presently under evaluation including targeted therapies, immunotherapies and vaccines. This review discusses briefly the current standards, newer updates as well as future prospective approaches in systemic therapies for cervical cancer. |
format | Online Article Text |
id | pubmed-9131767 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Wolters Kluwer - Medknow |
record_format | MEDLINE/PubMed |
spelling | pubmed-91317672022-05-26 Updates on systemic therapy for cervical cancer Gopu, Paul Antony, Febin Cyriac, Sunu Karakasis, Katherine Oza, Amit M. Indian J Med Res Review Article Cervical cancer is one of the most common cancers in the world both in terms of incidence and mortality, more so important in low- and middle-income countries. Surgery and radiotherapy remain the backbone of treatment for non-metastatic cervical cancer, with significant improvement in survival provided by addition of chemotherapy to radiotherapy. Survival as well as quality of life is improved by chemotherapy in metastatic disease. Platinum-based chemotherapy with/without bevacizumab is the mainstay of treatment for metastatic disease and has shown improvement in survival. The right combinations and sequence of treatment modalities and medicines are still evolving. Data regarding the molecular and genomic biology of cervical cancer have revealed multiple potential targets for treatment, and several new agents are presently under evaluation including targeted therapies, immunotherapies and vaccines. This review discusses briefly the current standards, newer updates as well as future prospective approaches in systemic therapies for cervical cancer. Wolters Kluwer - Medknow 2021-08 /pmc/articles/PMC9131767/ /pubmed/35295013 http://dx.doi.org/10.4103/ijmr.IJMR_4454_20 Text en Copyright: © 2022 Indian Journal of Medical Research https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms. |
spellingShingle | Review Article Gopu, Paul Antony, Febin Cyriac, Sunu Karakasis, Katherine Oza, Amit M. Updates on systemic therapy for cervical cancer |
title | Updates on systemic therapy for cervical cancer |
title_full | Updates on systemic therapy for cervical cancer |
title_fullStr | Updates on systemic therapy for cervical cancer |
title_full_unstemmed | Updates on systemic therapy for cervical cancer |
title_short | Updates on systemic therapy for cervical cancer |
title_sort | updates on systemic therapy for cervical cancer |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9131767/ https://www.ncbi.nlm.nih.gov/pubmed/35295013 http://dx.doi.org/10.4103/ijmr.IJMR_4454_20 |
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