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Model for surface-dependent factor XII activation: the roles of factor XII heavy chain domains

Factor XII (FXII) is the zymogen of a plasma protease (FXIIa) that contributes to bradykinin generation by converting prekallikrein to the protease plasma kallikrein (PKa). FXII conversion to FXIIa by autocatalysis or PKa-mediated cleavage is enhanced when the protein binds to negatively charged sur...

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Detalles Bibliográficos
Autores principales:	Shamanaev, Aleksandr, Ivanov, Ivan, Sun, Mao-Fu, Litvak, Maxim, Srivastava, Priyanka, Mohammed, Bassem M., Shaban, Rabia, Maddur, Ashoka, Verhamme, Ingrid M., McCarty, Owen J. T., Law, Ruby H. P., Gailani, David
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society of Hematology 2022
Materias:	Thrombosis and Hemostasis
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9131904/ https://www.ncbi.nlm.nih.gov/pubmed/35086137 http://dx.doi.org/10.1182/bloodadvances.2021005976

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