Patient-specific MDS-RS iPSCs define the mis-spliced transcript repertoire and chromatin landscape of SF3B1-mutant HSPCs

SF3B1(K700E) is the most frequent mutation in myelodysplastic syndrome (MDS), but the mechanisms by which it drives MDS pathogenesis remain unclear. We derived a panel of 18 genetically matched SF3B1(K700E)- and SF3B1(WT)-induced pluripotent stem cell (iPSC) lines from patients with MDS with ring si...

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Detalles Bibliográficos
Autores principales: Asimomitis, Georgios, Deslauriers, André G., Kotini, Andriana G., Bernard, Elsa, Esposito, Davide, Olszewska, Malgorzata, Spyrou, Nikolaos, Arango Ossa, Juan, Mortera-Blanco, Teresa, Koche, Richard, Nannya, Yasuhito, Malcovati, Luca, Ogawa, Seishi, Cazzola, Mario, Aaronson, Stuart A., Hellström-Lindberg, Eva, Papaemmanuil, Elli, Papapetrou, Eirini P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Hematology 2022
Materias:
Myeloid Neoplasia
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9131920/
https://www.ncbi.nlm.nih.gov/pubmed/35042235
http://dx.doi.org/10.1182/bloodadvances.2021006325

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