Metalloproteinase inhibition reduces AML growth, prevents stem cell loss, and improves chemotherapy effectiveness

Acute myeloid leukemia (AML) is a blood cancer of the myeloid lineage. Its prognosis remains poor, highlighting the need for new therapeutic and precision medicine approaches. AML symptoms often include cytopenias linked to loss of healthy hematopoietic stem and progenitor cells (HSPCs). The mechani...

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Detalles Bibliográficos
Autores principales: Pirillo, Chiara, Birch, Flora, Tissot, Floriane S., Anton, Sara Gonzalez, Haltalli, Myriam, Tini, Valentina, Kong, Isabella, Piot, Cécile, Partridge, Ben, Pospori, Constandina, Keeshan, Karen, Santamaria, Salvatore, Hawkins, Edwin, Falini, Brunangelo, Marra, Andrea, Duarte, Delfim, Lee, Chiu Fan, Roberts, Edward, Lo Celso, Cristina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Hematology 2022
Materias:
Myeloid Neoplasia
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9131921/
https://www.ncbi.nlm.nih.gov/pubmed/35157757
http://dx.doi.org/10.1182/bloodadvances.2021004321

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9131921/
https://www.ncbi.nlm.nih.gov/pubmed/35157757
http://dx.doi.org/10.1182/bloodadvances.2021004321

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