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The B7 family molecules in oral squamous cell carcinoma: a systematic review. Part I: B7-H1 (PD-L1) and B7-DC (PD-L2)

INTRODUCTION: Oral squamous cell carcinoma (OSCC) is the most common cancerous lesion in the oral cavity. During recent years, no significant reduction in the survival rate has been observed. AIM: To systematically review the literature and to summarise correlations between B7 family proteins and pr...

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Autores principales: Starzyńska, Anna, Sejda, Aleksandra, Adamski, Łukasz, Adamska, Paulina, Pęksa, Rafał, Sakowicz-Burkiewicz, Monika, Wychowański, Piotr, Jereczek-Fossa, Barbara A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Termedia Publishing House 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9131943/
https://www.ncbi.nlm.nih.gov/pubmed/35645666
http://dx.doi.org/10.5114/ada.2020.98522
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author Starzyńska, Anna
Sejda, Aleksandra
Adamski, Łukasz
Adamska, Paulina
Pęksa, Rafał
Sakowicz-Burkiewicz, Monika
Wychowański, Piotr
Jereczek-Fossa, Barbara A.
author_facet Starzyńska, Anna
Sejda, Aleksandra
Adamski, Łukasz
Adamska, Paulina
Pęksa, Rafał
Sakowicz-Burkiewicz, Monika
Wychowański, Piotr
Jereczek-Fossa, Barbara A.
author_sort Starzyńska, Anna
collection PubMed
description INTRODUCTION: Oral squamous cell carcinoma (OSCC) is the most common cancerous lesion in the oral cavity. During recent years, no significant reduction in the survival rate has been observed. AIM: To systematically review the literature and to summarise correlations between B7 family proteins and prognosis in OSCC. MATERIAL AND METHODS: A systematic review of the literature about B7-H1 (PD-L1) and B7-DC (PD-L2) was carried out, following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Thirty-six articles published before 22 May 2020 were included in the systematic review. RESULTS: The biggest study group consisted of 305 patients and the smallest – 10 patients. PD-L1 proved to be a prognostic factor in patients with OSCC. Immunohistochemistry was the most commonly used diagnostic method. CONCLUSIONS: Any mutations in the gene encoding PD-L1 and quantitative or functional changes in the status of PD-L1 may be important in the prognosis of OSCC.
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spelling pubmed-91319432022-05-26 The B7 family molecules in oral squamous cell carcinoma: a systematic review. Part I: B7-H1 (PD-L1) and B7-DC (PD-L2) Starzyńska, Anna Sejda, Aleksandra Adamski, Łukasz Adamska, Paulina Pęksa, Rafał Sakowicz-Burkiewicz, Monika Wychowański, Piotr Jereczek-Fossa, Barbara A. Postepy Dermatol Alergol Original Paper INTRODUCTION: Oral squamous cell carcinoma (OSCC) is the most common cancerous lesion in the oral cavity. During recent years, no significant reduction in the survival rate has been observed. AIM: To systematically review the literature and to summarise correlations between B7 family proteins and prognosis in OSCC. MATERIAL AND METHODS: A systematic review of the literature about B7-H1 (PD-L1) and B7-DC (PD-L2) was carried out, following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Thirty-six articles published before 22 May 2020 were included in the systematic review. RESULTS: The biggest study group consisted of 305 patients and the smallest – 10 patients. PD-L1 proved to be a prognostic factor in patients with OSCC. Immunohistochemistry was the most commonly used diagnostic method. CONCLUSIONS: Any mutations in the gene encoding PD-L1 and quantitative or functional changes in the status of PD-L1 may be important in the prognosis of OSCC. Termedia Publishing House 2020-10-13 2022-04 /pmc/articles/PMC9131943/ /pubmed/35645666 http://dx.doi.org/10.5114/ada.2020.98522 Text en Copyright: © 2022 Termedia Sp. z o. o. https://creativecommons.org/licenses/by-nc-sa/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) License, allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material, provided the original work is properly cited and states its license.
spellingShingle Original Paper
Starzyńska, Anna
Sejda, Aleksandra
Adamski, Łukasz
Adamska, Paulina
Pęksa, Rafał
Sakowicz-Burkiewicz, Monika
Wychowański, Piotr
Jereczek-Fossa, Barbara A.
The B7 family molecules in oral squamous cell carcinoma: a systematic review. Part I: B7-H1 (PD-L1) and B7-DC (PD-L2)
title The B7 family molecules in oral squamous cell carcinoma: a systematic review. Part I: B7-H1 (PD-L1) and B7-DC (PD-L2)
title_full The B7 family molecules in oral squamous cell carcinoma: a systematic review. Part I: B7-H1 (PD-L1) and B7-DC (PD-L2)
title_fullStr The B7 family molecules in oral squamous cell carcinoma: a systematic review. Part I: B7-H1 (PD-L1) and B7-DC (PD-L2)
title_full_unstemmed The B7 family molecules in oral squamous cell carcinoma: a systematic review. Part I: B7-H1 (PD-L1) and B7-DC (PD-L2)
title_short The B7 family molecules in oral squamous cell carcinoma: a systematic review. Part I: B7-H1 (PD-L1) and B7-DC (PD-L2)
title_sort b7 family molecules in oral squamous cell carcinoma: a systematic review. part i: b7-h1 (pd-l1) and b7-dc (pd-l2)
topic Original Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9131943/
https://www.ncbi.nlm.nih.gov/pubmed/35645666
http://dx.doi.org/10.5114/ada.2020.98522
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