A dominant negative splice variant of the heparan sulfate biosynthesis enzyme NDST1 reduces heparan sulfate sulfation

NDST1 (glucosaminyl N-deacetylase/N-sulfotransferase) is a key enzyme in heparan sulfate (HS) biosynthesis, where it is responsible for HS N-deacetylation and N-sulfation. In addition to the full length human enzyme of 882 amino acids, here designated NDST1A, a shorter form containing 825 amino acid...

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Detalles Bibliográficos
Autores principales: Missaghian, Parisa, Dierker, Tabea, Khosrowabadi, Elham, Axling, Fredrik, Eriksson, Inger, Ghanem, Abdurrahman, Kusche-Gullberg, Marion, Kellokumpu, Sakari, Kjellén, Lena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9132247/
https://www.ncbi.nlm.nih.gov/pubmed/35137078
http://dx.doi.org/10.1093/glycob/cwac004

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