Merkel cell polyomavirus large T antigen binding to pRb promotes skin hyperplasia and tumor development

Clear evidence supports a causal link between Merkel cell polyomavirus (MCPyV) and the highly aggressive human skin cancer called Merkel cell carcinoma (MCC). Integration of viral DNA into the human genome facilitates continued expression of the MCPyV small tumor (ST) and large tumor (LT) antigens i...

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Detalles Bibliográficos
Autores principales: Spurgeon, Megan E., Cheng, Jingwei, Ward-Shaw, Ella, Dick, Frederick A., DeCaprio, James A., Lambert, Paul F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9132321/
https://www.ncbi.nlm.nih.gov/pubmed/35560034
http://dx.doi.org/10.1371/journal.ppat.1010551

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