Spelling out the roles of individual nucleoporins in nuclear export of mRNA

The Nuclear Pore Complex (NPC) represents a critical passage through the nuclear envelope for nuclear import and export that impacts nearly every cellular process at some level. Recent technological advances in the form of Auxin Inducible Degron (AID) strategies and Single-Point Edge-Excitation sub-...

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Detalles Bibliográficos
Autores principales: Tingey, Mark, Li, Yichen, Yu, Wenlan, Young, Albert, Yang, Weidong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9132428/
https://www.ncbi.nlm.nih.gov/pubmed/35593254
http://dx.doi.org/10.1080/19491034.2022.2076965
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author Tingey, Mark
Li, Yichen
Yu, Wenlan
Young, Albert
Yang, Weidong
author_facet Tingey, Mark
Li, Yichen
Yu, Wenlan
Young, Albert
Yang, Weidong
author_sort Tingey, Mark
collection PubMed
description The Nuclear Pore Complex (NPC) represents a critical passage through the nuclear envelope for nuclear import and export that impacts nearly every cellular process at some level. Recent technological advances in the form of Auxin Inducible Degron (AID) strategies and Single-Point Edge-Excitation sub-Diffraction (SPEED) microscopy have enabled us to provide new insight into the distinct functions and roles of nuclear basket nucleoporins (Nups) upon nuclear docking and export for mRNAs. In this paper, we provide a review of our recent findings as well as an assessment of new techniques, updated models, and future perspectives in the studies of mRNA’s nuclear export.
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spelling pubmed-91324282022-05-26 Spelling out the roles of individual nucleoporins in nuclear export of mRNA Tingey, Mark Li, Yichen Yu, Wenlan Young, Albert Yang, Weidong Nucleus Review The Nuclear Pore Complex (NPC) represents a critical passage through the nuclear envelope for nuclear import and export that impacts nearly every cellular process at some level. Recent technological advances in the form of Auxin Inducible Degron (AID) strategies and Single-Point Edge-Excitation sub-Diffraction (SPEED) microscopy have enabled us to provide new insight into the distinct functions and roles of nuclear basket nucleoporins (Nups) upon nuclear docking and export for mRNAs. In this paper, we provide a review of our recent findings as well as an assessment of new techniques, updated models, and future perspectives in the studies of mRNA’s nuclear export. Taylor & Francis 2022-05-20 /pmc/articles/PMC9132428/ /pubmed/35593254 http://dx.doi.org/10.1080/19491034.2022.2076965 Text en © 2022 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Tingey, Mark
Li, Yichen
Yu, Wenlan
Young, Albert
Yang, Weidong
Spelling out the roles of individual nucleoporins in nuclear export of mRNA
title Spelling out the roles of individual nucleoporins in nuclear export of mRNA
title_full Spelling out the roles of individual nucleoporins in nuclear export of mRNA
title_fullStr Spelling out the roles of individual nucleoporins in nuclear export of mRNA
title_full_unstemmed Spelling out the roles of individual nucleoporins in nuclear export of mRNA
title_short Spelling out the roles of individual nucleoporins in nuclear export of mRNA
title_sort spelling out the roles of individual nucleoporins in nuclear export of mrna
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9132428/
https://www.ncbi.nlm.nih.gov/pubmed/35593254
http://dx.doi.org/10.1080/19491034.2022.2076965
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