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Synthetic gene circuits for preventing disruption of the circadian clock due to interleukin-1–induced inflammation
The circadian clock regulates tissue homeostasis through temporal control of tissue-specific clock-controlled genes. In articular cartilage, disruptions in the circadian clock are linked to a procatabolic state. In the presence of inflammation, the cartilage circadian clock is disrupted, which furth...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Association for the Advancement of Science
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9132444/ https://www.ncbi.nlm.nih.gov/pubmed/35613259 http://dx.doi.org/10.1126/sciadv.abj8892 |