Selective endocytosis of Ca(2+)-permeable AMPARs by the Alzheimer’s disease risk factor CALM bidirectionally controls synaptic plasticity

AMPA-type glutamate receptors (AMPARs) mediate fast excitatory neurotransmission, and the plastic modulation of their surface levels determines synaptic strength. AMPARs of different subunit compositions fulfill distinct roles in synaptic long-term potentiation (LTP) and depression (LTD) to enable l...

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Detalles Bibliográficos
Autores principales: Azarnia Tehran, Domenico, Kochlamazashvili, Gaga, Pampaloni, Niccolò P., Sposini, Silvia, Shergill, Jasmeet Kaur, Lehmann, Martin, Pashkova, Natalya, Schmidt, Claudia, Löwe, Delia, Napieczynska, Hanna, Heuser, Arnd, Plested, Andrew J. R., Perrais, David, Piper, Robert C., Haucke, Volker, Maritzen, Tanja
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2022
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9132451/
https://www.ncbi.nlm.nih.gov/pubmed/35613266
http://dx.doi.org/10.1126/sciadv.abl5032

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