Actin-binding protein filamin-A drives tau aggregation and contributes to progressive supranuclear palsy pathology

While amyloid-β lies upstream of tau pathology in Alzheimer’s disease, key drivers for other tauopathies, including progressive supranuclear palsy (PSP), are largely unknown. Various tau mutations are known to facilitate tau aggregation, but how the nonmutated tau, which most cases with PSP share, i...

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Detalles Bibliográficos
Autores principales: Tsujikawa, Koyo, Hamanaka, Kohei, Riku, Yuichi, Hattori, Yuki, Hara, Norikazu, Iguchi, Yohei, Ishigaki, Shinsuke, Hashizume, Atsushi, Miyatake, Satoko, Mitsuhashi, Satomi, Miyazaki, Yu, Kataoka, Mayumi, Jiayi, Li, Yasui, Keizo, Kuru, Satoshi, Koike, Haruki, Kobayashi, Kenta, Sahara, Naruhiko, Ozaki, Norio, Yoshida, Mari, Kakita, Akiyoshi, Saito, Yuko, Iwasaki, Yasushi, Miyashita, Akinori, Iwatsubo, Takeshi, Ikeuchi, Takeshi, Miyata, Takaki, Sobue, Gen, Matsumoto, Naomichi, Sahashi, Kentaro, Katsuno, Masahisa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2022
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9132466/
https://www.ncbi.nlm.nih.gov/pubmed/35613261
http://dx.doi.org/10.1126/sciadv.abm5029

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