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A Retrospective Study on Mandibular Reconstruction Following Excision of Canine Acanthomatous Ameloblastoma

The successful excision of a locally invasive tumor such as canine acanthomatous ameloblastoma (CAA) typically results in a mandibular contour-derforming, critical-size defect that alters the jaw kinematics, and may affect the patient's quality of life. In this case series, we describe our expe...

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Autores principales: Tsugawa, Anson J., Arzi, Boaz, Vapniarsky, Natalia, Verstraete, Frank J. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9132539/
https://www.ncbi.nlm.nih.gov/pubmed/35647098
http://dx.doi.org/10.3389/fvets.2022.900031
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author Tsugawa, Anson J.
Arzi, Boaz
Vapniarsky, Natalia
Verstraete, Frank J. M.
author_facet Tsugawa, Anson J.
Arzi, Boaz
Vapniarsky, Natalia
Verstraete, Frank J. M.
author_sort Tsugawa, Anson J.
collection PubMed
description The successful excision of a locally invasive tumor such as canine acanthomatous ameloblastoma (CAA) typically results in a mandibular contour-derforming, critical-size defect that alters the jaw kinematics, and may affect the patient's quality of life. In this case series, we describe our experience using the regenerative approach of a titanium locking plate and compression resistant matrix infused with rhBMP-2 for the immediate or delayed reconstruction following mandibulectomy for the excision of mandibular CAA in 11 dogs. Surgical planning included computed tomography (CT), with and without contrast, in all cases, and 3D-printed models in four cases. Tumor-free surgical margins were achieved in all dogs. Clinical and diagnostic imaging follow-up (mean, 23.1 months) were performed in-person (11 cases) and with CT/cone-beam computed tomography in most cases, with standard radiography (3 cases) and telemedicine being utilized in 5 cases. At 2 weeks postoperatively, hard tissue was palpable at the defect. Follow-up imaging at 1 month postoperatively revealed evidence of bridging new bone with a heterogeneous appearance, that remodeled over 3–6 months to bone of a similar size, shape and trabecular pattern as native bone. Histological evaluation of regenerated bone was available in two cases, and was supportive of our clinical and imaging findings of normal remodeled bone. Clinically, all dogs returned to a normal lifestyle, rapidly resumed eating and drinking, and exhibited normal occlusion. Complications included wound dehiscence in one dog and self-limiting exuberant bone formation in two dogs. Tumor regrowth, failure of the implant or fracture of the regenerated bone were not observed. We conclude that the mandibular reconstruction using a regenerative approach is safe, feasible, and results in restoration of mandibular contour in dogs following segmental and bilateral rostral mandibulectomy for benign but invasive oral tumors such as CAA.
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spelling pubmed-91325392022-05-26 A Retrospective Study on Mandibular Reconstruction Following Excision of Canine Acanthomatous Ameloblastoma Tsugawa, Anson J. Arzi, Boaz Vapniarsky, Natalia Verstraete, Frank J. M. Front Vet Sci Veterinary Science The successful excision of a locally invasive tumor such as canine acanthomatous ameloblastoma (CAA) typically results in a mandibular contour-derforming, critical-size defect that alters the jaw kinematics, and may affect the patient's quality of life. In this case series, we describe our experience using the regenerative approach of a titanium locking plate and compression resistant matrix infused with rhBMP-2 for the immediate or delayed reconstruction following mandibulectomy for the excision of mandibular CAA in 11 dogs. Surgical planning included computed tomography (CT), with and without contrast, in all cases, and 3D-printed models in four cases. Tumor-free surgical margins were achieved in all dogs. Clinical and diagnostic imaging follow-up (mean, 23.1 months) were performed in-person (11 cases) and with CT/cone-beam computed tomography in most cases, with standard radiography (3 cases) and telemedicine being utilized in 5 cases. At 2 weeks postoperatively, hard tissue was palpable at the defect. Follow-up imaging at 1 month postoperatively revealed evidence of bridging new bone with a heterogeneous appearance, that remodeled over 3–6 months to bone of a similar size, shape and trabecular pattern as native bone. Histological evaluation of regenerated bone was available in two cases, and was supportive of our clinical and imaging findings of normal remodeled bone. Clinically, all dogs returned to a normal lifestyle, rapidly resumed eating and drinking, and exhibited normal occlusion. Complications included wound dehiscence in one dog and self-limiting exuberant bone formation in two dogs. Tumor regrowth, failure of the implant or fracture of the regenerated bone were not observed. We conclude that the mandibular reconstruction using a regenerative approach is safe, feasible, and results in restoration of mandibular contour in dogs following segmental and bilateral rostral mandibulectomy for benign but invasive oral tumors such as CAA. Frontiers Media S.A. 2022-05-11 /pmc/articles/PMC9132539/ /pubmed/35647098 http://dx.doi.org/10.3389/fvets.2022.900031 Text en Copyright © 2022 Tsugawa, Arzi, Vapniarsky and Verstraete. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Veterinary Science
Tsugawa, Anson J.
Arzi, Boaz
Vapniarsky, Natalia
Verstraete, Frank J. M.
A Retrospective Study on Mandibular Reconstruction Following Excision of Canine Acanthomatous Ameloblastoma
title A Retrospective Study on Mandibular Reconstruction Following Excision of Canine Acanthomatous Ameloblastoma
title_full A Retrospective Study on Mandibular Reconstruction Following Excision of Canine Acanthomatous Ameloblastoma
title_fullStr A Retrospective Study on Mandibular Reconstruction Following Excision of Canine Acanthomatous Ameloblastoma
title_full_unstemmed A Retrospective Study on Mandibular Reconstruction Following Excision of Canine Acanthomatous Ameloblastoma
title_short A Retrospective Study on Mandibular Reconstruction Following Excision of Canine Acanthomatous Ameloblastoma
title_sort retrospective study on mandibular reconstruction following excision of canine acanthomatous ameloblastoma
topic Veterinary Science
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9132539/
https://www.ncbi.nlm.nih.gov/pubmed/35647098
http://dx.doi.org/10.3389/fvets.2022.900031
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