A point mutation in the nucleotide exchange factor eIF2B constitutively activates the integrated stress response by allosteric modulation

In eukaryotic cells, stressors reprogram the cellular proteome by activating the integrated stress response (ISR). In its canonical form, stress-sensing kinases phosphorylate the eukaryotic translation initiation factor eIF2 (eIF2-P), which ultimately leads to reduced levels of ternary complex requi...

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Detalles Bibliográficos
Autores principales: Boone, Morgane, Wang, Lan, Lawrence, Rosalie E, Frost, Adam, Walter, Peter, Schoof, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2022
Materias:
Biochemistry and Chemical Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9132573/
https://www.ncbi.nlm.nih.gov/pubmed/35416150
http://dx.doi.org/10.7554/eLife.76171

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9132573/
https://www.ncbi.nlm.nih.gov/pubmed/35416150
http://dx.doi.org/10.7554/eLife.76171

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