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A point mutation in the nucleotide exchange factor eIF2B constitutively activates the integrated stress response by allosteric modulation
In eukaryotic cells, stressors reprogram the cellular proteome by activating the integrated stress response (ISR). In its canonical form, stress-sensing kinases phosphorylate the eukaryotic translation initiation factor eIF2 (eIF2-P), which ultimately leads to reduced levels of ternary complex requi...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
eLife Sciences Publications, Ltd
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9132573/ https://www.ncbi.nlm.nih.gov/pubmed/35416150 http://dx.doi.org/10.7554/eLife.76171 |