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Burden and Associated Genotype Patterns of High-Risk Human Papilloma Virus Infection and Cervical Cytology Abnormalities among Women in Central India

BACKGROUND: The epidemiology of human papilloma virus (HPV) infection and the pattern of HPV genotype distribution are much-needed parameters to assess the risk of cervical cancer among females. However, due to less availability of data on HPV burden and its genotypes from various geographical regio...

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Autores principales: Gupta, Shipra, Purwar, Shashank, Gupta, Priyal, Halder, Ajay, Gupta, Ayush, Pushpalatha, K., John, Julie Hansa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9132658/
https://www.ncbi.nlm.nih.gov/pubmed/35634175
http://dx.doi.org/10.1155/2022/3932110
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author Gupta, Shipra
Purwar, Shashank
Gupta, Priyal
Halder, Ajay
Gupta, Ayush
Pushpalatha, K.
John, Julie Hansa
author_facet Gupta, Shipra
Purwar, Shashank
Gupta, Priyal
Halder, Ajay
Gupta, Ayush
Pushpalatha, K.
John, Julie Hansa
author_sort Gupta, Shipra
collection PubMed
description BACKGROUND: The epidemiology of human papilloma virus (HPV) infection and the pattern of HPV genotype distribution are much-needed parameters to assess the risk of cervical cancer among females. However, due to less availability of data on HPV burden and its genotypes from various geographical regions in India makes cervical cancer screening modalities and vaccination strategies difficult to implement. OBJECTIVE: The present study was conducted to identify the various genotypes particularly high-risk HPV types in premalignant or malignant cervical lesions. METHODS: The study was a hospital-based cross-sectional study wherein 295 symptomatic women were screened by Pap smear and multiplex real-time PCR was performed for HPV genotypes identification in women with abnormal cervical cytology. RESULTS: Out of 295 women, 237 (80.3%), 45 (15.3%), and 13 (4.4%) women had normal Pap smear, squamous cell carcinoma and precancerous cytology, respectively. Among these 58 women having abnormal cervical cytology, HPV was detected in 48 (81.0%) participants. Most common HPV genotypes in our study were HPV 16 (n = 29; 60.4%) followed by mixed infections; i.e., more than one type of HPV was detected (n = 10, 20.8%). HPV 18 was detected only in 6.25%, whereas other high-risk HPV genotypes were found to be 12.5%. CONCLUSION: HPV positivity was >80% in women having abnormal Pap smear. The prevalence of HPV 18 was found to be much less in Central India, compared to other parts of country. HPV 16 was the most common genotype followed by mixed HPV genotype infections. It is evident from our study that symptomatic women even if having normal Pap smear should be screened for HPV and followed up with periodic Pap smears for detecting any change in cervical cytology, thus preventing cervical cancer in women.
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spelling pubmed-91326582022-05-26 Burden and Associated Genotype Patterns of High-Risk Human Papilloma Virus Infection and Cervical Cytology Abnormalities among Women in Central India Gupta, Shipra Purwar, Shashank Gupta, Priyal Halder, Ajay Gupta, Ayush Pushpalatha, K. John, Julie Hansa Infect Dis Obstet Gynecol Research Article BACKGROUND: The epidemiology of human papilloma virus (HPV) infection and the pattern of HPV genotype distribution are much-needed parameters to assess the risk of cervical cancer among females. However, due to less availability of data on HPV burden and its genotypes from various geographical regions in India makes cervical cancer screening modalities and vaccination strategies difficult to implement. OBJECTIVE: The present study was conducted to identify the various genotypes particularly high-risk HPV types in premalignant or malignant cervical lesions. METHODS: The study was a hospital-based cross-sectional study wherein 295 symptomatic women were screened by Pap smear and multiplex real-time PCR was performed for HPV genotypes identification in women with abnormal cervical cytology. RESULTS: Out of 295 women, 237 (80.3%), 45 (15.3%), and 13 (4.4%) women had normal Pap smear, squamous cell carcinoma and precancerous cytology, respectively. Among these 58 women having abnormal cervical cytology, HPV was detected in 48 (81.0%) participants. Most common HPV genotypes in our study were HPV 16 (n = 29; 60.4%) followed by mixed infections; i.e., more than one type of HPV was detected (n = 10, 20.8%). HPV 18 was detected only in 6.25%, whereas other high-risk HPV genotypes were found to be 12.5%. CONCLUSION: HPV positivity was >80% in women having abnormal Pap smear. The prevalence of HPV 18 was found to be much less in Central India, compared to other parts of country. HPV 16 was the most common genotype followed by mixed HPV genotype infections. It is evident from our study that symptomatic women even if having normal Pap smear should be screened for HPV and followed up with periodic Pap smears for detecting any change in cervical cytology, thus preventing cervical cancer in women. Hindawi 2022-05-18 /pmc/articles/PMC9132658/ /pubmed/35634175 http://dx.doi.org/10.1155/2022/3932110 Text en Copyright © 2022 Shipra Gupta et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Gupta, Shipra
Purwar, Shashank
Gupta, Priyal
Halder, Ajay
Gupta, Ayush
Pushpalatha, K.
John, Julie Hansa
Burden and Associated Genotype Patterns of High-Risk Human Papilloma Virus Infection and Cervical Cytology Abnormalities among Women in Central India
title Burden and Associated Genotype Patterns of High-Risk Human Papilloma Virus Infection and Cervical Cytology Abnormalities among Women in Central India
title_full Burden and Associated Genotype Patterns of High-Risk Human Papilloma Virus Infection and Cervical Cytology Abnormalities among Women in Central India
title_fullStr Burden and Associated Genotype Patterns of High-Risk Human Papilloma Virus Infection and Cervical Cytology Abnormalities among Women in Central India
title_full_unstemmed Burden and Associated Genotype Patterns of High-Risk Human Papilloma Virus Infection and Cervical Cytology Abnormalities among Women in Central India
title_short Burden and Associated Genotype Patterns of High-Risk Human Papilloma Virus Infection and Cervical Cytology Abnormalities among Women in Central India
title_sort burden and associated genotype patterns of high-risk human papilloma virus infection and cervical cytology abnormalities among women in central india
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9132658/
https://www.ncbi.nlm.nih.gov/pubmed/35634175
http://dx.doi.org/10.1155/2022/3932110
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