Cargando…

Targeting the Axl and mTOR Pathway Synergizes Immunotherapy and Chemotherapy to Butylidenephthalide in a Recurrent GBM

BACKGROUND: The role of inherent tumor heterogeneity and an immunosuppressive microenvironment in therapeutic resistance has been determined to be of importance for the better management of glioblastoma multiforme (GBM). Some studies have suggested that combined drugs with divergent mechanisms may b...

Descripción completa

Detalles Bibliográficos
Autores principales:	Liu, Ching-Ann, Harn, Horng-Jyh, Chen, Kuan-Pin, Lee, Jui-Hao, Lin, Shinn-Zong, Chiu, Tsung-Lang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9132698/ https://www.ncbi.nlm.nih.gov/pubmed/35646111 http://dx.doi.org/10.1155/2022/3236058

Ejemplares similares

n-Butylidenephthalide Modulates Autophagy to Ameliorate Neuropathological Progress of Spinocerebellar Ataxia Type 3 through mTOR Pathway
por: Lee, Jui-Hao, et al.
Publicado: (2021)

n-Butylidenephthalide Regulated Tumor Stem Cell Genes EZH2/AXL and Reduced Its Migration and Invasion in Glioblastoma
por: Yen, Ssu-Yin, et al.
Publicado: (2017)

Induction of Apoptosis Coupled to Endoplasmic Reticulum Stress in Human Prostate Cancer Cells by n-butylidenephthalide
por: Chiu, Sheng-Chun, et al.
Publicado: (2012)

The Role of Butylidenephthalide in Targeting the Microenvironment Which Contributes to Liver Fibrosis Amelioration
por: Chuang, Hong-Meng, et al.
Publicado: (2016)

The natural compound n-butylidenephthalide derived from Angelica sinensis inhibits malignant brain tumor growth in vitro and in vivo3
por: Tsai, Nu-Man, et al.
Publicado: (2006)

Butylidenephthalide Abrogates the Snail-Induced Cancer Stemness in Oral Carcinomas
por: Chen, Pei-Yin, et al.
Publicado: (2022)

Non-Canonical Regulation of Type I Collagen through Promoter Binding of SOX2 and Its Contribution to Ameliorating Pulmonary Fibrosis by Butylidenephthalide
por: Chuang, Hong-Meng, et al.
Publicado: (2018)

N-butylidenephthalide Attenuates Alzheimer's Disease-Like Cytopathy in Down Syndrome Induced Pluripotent Stem Cell-Derived Neurons
por: Chang, Chia-Yu, et al.
Publicado: (2015)

N-Butylidenephthalide Inhibits the Phenotypic Switch of VSMCs through Activation of AMPK and Prevents Stenosis in an Arteriovenous Fistula Rat Model
por: Yang, Hsin-Han, et al.
Publicado: (2020)

n-Butylidenephthalide (BP) Maintains Stem Cell Pluripotency by Activating Jak2/Stat3 Pathway and Increases the Efficiency of iPS Cells Generation
por: Liu, Shih-Ping, et al.
Publicado: (2012)

n-Butylidenephthalide Protects against Dopaminergic Neuron Degeneration and α-Synuclein Accumulation in Caenorhabditis elegans Models of Parkinson's Disease
por: Fu, Ru-Huei, et al.
Publicado: (2014)

Anti-Excitotoxic Effects of N-Butylidenephthalide Revealed by Chemically Insulted Purkinje Progenitor Cells Derived from SCA3 iPSCs
por: Yang, Hsin-Han, et al.
Publicado: (2022)

Effect of lithium on ventricular remodelling in infarcted rats via the Akt/mTOR signalling pathways
por: Lee, Tsung-Ming, et al.
Publicado: (2017)

Anti-Tumor and Radiosensitization Effects of N-Butylidenephthalide on Human Breast Cancer Cells
por: Su, Yi-Ju, et al.
Publicado: (2018)

Potential therapeutic effects of N-butylidenephthalide from Radix Angelica Sinensis (Danggui) in human bladder cancer cells
por: Chiu, Sheng-Chun, et al.
Publicado: (2017)

Advances in Patient-Specific Induced Pluripotent Stem Cells Shed Light on Drug Discovery for Amyotrophic Lateral Sclerosis
por: Lee, Jui-Hao, et al.
Publicado: (2018)

Identifying Therapeutic Targets for Spinocerebellar Ataxia Type 3/Machado–Joseph Disease through Integration of Pathological Biomarkers and Therapeutic Strategies
por: Chen, Yu-Shuan, et al.
Publicado: (2020)

Chinese herbs and acupuncture to improve cognitive function in Alzheimer's disease
por: WuLi, Wei, et al.
Publicado: (2021)

Hispolon Induces Apoptosis, Suppresses Migration and Invasion of Glioblastoma Cells and Inhibits GBM Xenograft Tumor Growth In Vivo
por: Liao, Kuan-Fu, et al.
Publicado: (2021)

Adipose-derived Stem Cells Stimulated with n-Butylidenephthalide Exhibit Therapeutic Effects in a Mouse Model of Parkinson’s Disease
por: Chi, Kang, et al.
Publicado: (2018)

Immunotherapy: rAAV2 expressing interleukin-15 inhibits HeLa cell tumor growth in mice
por: Yiang, Giou-Teng, et al.
Publicado: (2009)

Combined inhibition of MEK and mTOR has a synergic effect on angiosarcoma tumorgrafts
por: ANDERSEN, NICHOLAS J., et al.
Publicado: (2015)

Interstitial Control-Released Polymer Carrying a Targeting Small-Molecule Drug Reduces PD-L1 and MGMT Expression in Recurrent High-Grade Gliomas with TMZ Resistance
por: Liu, Ching-Ann, et al.
Publicado: (2022)

Exosomes and Stem Cells in Degenerative Disease Diagnosis and Therapy
por: Chang, Yu-Hsun, et al.
Publicado: (2018)

Deep Brain Stimulation for Amelioration of Cognitive Impairment in Neurological Disorders: Neurogenesis and Circuit Reanimation
por: Tsai, Sheng-Tzung, et al.
Publicado: (2018)

Targeting the IGF/PI3K/mTOR pathway and AXL/YAP1/TAZ pathways in primary bone cancer
por: Truong, Danh D., et al.
Publicado: (2022)

Targeting cytomegalovirus (CMV) antigens for GBM immunotherapy
por: Nair, Smita K, et al.
Publicado: (2013)

Synergism between the mTOR inhibitor rapamycin and FAK down-regulation in the treatment of acute lymphoblastic leukemia
por: Shi, Pei-Jie, et al.
Publicado: (2016)

Effect of Cinnamomum osmophloeum Kanehira Leaf Aqueous Extract on Dermal Papilla Cell Proliferation and Hair Growth
por: Wen, Tung-Chou, et al.
Publicado: (2018)

Biomimetic GBM-targeted drug delivery system boosting ferroptosis for immunotherapy of orthotopic drug-resistant GBM
por: Liu, Bao, et al.
Publicado: (2022)

Cnidium officinale extract and butylidenephthalide inhibits retinal neovascularization in vitro and in vivo
por: Lee, Yun Mi, et al.
Publicado: (2016)

Mechanisms of butylidenephthalide for twitch facilitation in electrically stimulated mouse vas deferens
por: Shih, Chung-Hung, et al.
Publicado: (2018)

Antitumor Effects of N-Butylidenephthalide Encapsulated in Lipopolyplexs in Colorectal Cancer Cells
por: Chang, Kai-Fu, et al.
Publicado: (2020)

Effects of Moxibustion on the Levels of Insulin-Like Growth Factor 1: A Pilot Study
por: Lin, Jaung-Geng, et al.
Publicado: (2018)

Randomized Controlled Immunotherapy Clinical Trials for GBM Challenged
por: Van Gool, Stefaan W., et al.
Publicado: (2020)

MDM2 antagonists synergize with PI3K/mTOR inhibition in well-differentiated/dedifferentiated liposarcomas
por: Laroche, Audrey, et al.
Publicado: (2017)

Induced Pluripotent Stem Cell (iPSC)-Based Neurodegenerative Disease Models for Phenotype Recapitulation and Drug Screening
por: Chang, Chia-Yu, et al.
Publicado: (2020)

Remote transplantation of human adipose-derived stem cells induces regression of cardiac hypertrophy by regulating the macrophage polarization in spontaneously hypertensive rats
por: Lee, Tsung-Ming, et al.
Publicado: (2019)

Host pre‐conditioning improves human adipose–derived stem cell transplantation in ageing rats after myocardial infarction: Role of NLRP3 inflammasome
por: Lee, Tsung‐Ming, et al.
Publicado: (2020)

Differentiation of Human Pluripotent Stem Cells Into Specific Neural Lineages
por: Chang, Chia-Yu, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_rcp4pem6b10tfrv1udmqvp2jmh