Accounting for the genetic load in assisted reproductive technology

The genetic load in the human genome has important ramifications for assisted reproductive technology (ART), human reproduction and fertility more generally. Here, we discuss these topics in the light of evolutionary genetic theory, the technological revolution in ART and the advances in the fields...

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Detalles Bibliográficos
Autores principales: van Oosterhout, Cock, Marcu, Daniel, Immler, Simone
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9132725/
https://www.ncbi.nlm.nih.gov/pubmed/35613708
http://dx.doi.org/10.1002/ctm2.864
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author van Oosterhout, Cock
Marcu, Daniel
Immler, Simone
author_facet van Oosterhout, Cock
Marcu, Daniel
Immler, Simone
author_sort van Oosterhout, Cock
collection PubMed
description The genetic load in the human genome has important ramifications for assisted reproductive technology (ART), human reproduction and fertility more generally. Here, we discuss these topics in the light of evolutionary genetic theory, the technological revolution in ART and the advances in the fields of genomics and bioinformatics.
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spelling pubmed-91327252022-05-26 Accounting for the genetic load in assisted reproductive technology van Oosterhout, Cock Marcu, Daniel Immler, Simone Clin Transl Med Commentary The genetic load in the human genome has important ramifications for assisted reproductive technology (ART), human reproduction and fertility more generally. Here, we discuss these topics in the light of evolutionary genetic theory, the technological revolution in ART and the advances in the fields of genomics and bioinformatics. John Wiley and Sons Inc. 2022-05-25 /pmc/articles/PMC9132725/ /pubmed/35613708 http://dx.doi.org/10.1002/ctm2.864 Text en © 2022 The Authors. Clinical and Translational Medicine published by John Wiley & Sons Australia, Ltd on behalf of Shanghai Institute of Clinical Bioinformatics. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Commentary
van Oosterhout, Cock
Marcu, Daniel
Immler, Simone
Accounting for the genetic load in assisted reproductive technology
title Accounting for the genetic load in assisted reproductive technology
title_full Accounting for the genetic load in assisted reproductive technology
title_fullStr Accounting for the genetic load in assisted reproductive technology
title_full_unstemmed Accounting for the genetic load in assisted reproductive technology
title_short Accounting for the genetic load in assisted reproductive technology
title_sort accounting for the genetic load in assisted reproductive technology
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9132725/
https://www.ncbi.nlm.nih.gov/pubmed/35613708
http://dx.doi.org/10.1002/ctm2.864
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