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Assessment of the humoral immunity induced by Sputnik V Covid-19 vaccine (GAM-COVID-VAC) in healthcare workers()

BACKGROUND: Vaccination for COVID-19 in healthcare workers (HCW) is essential to protect one of the populations most exposed to this disease. However, data on the humoral response rate to the vaccine and the factors associated with it in this population are limited. Therefore, we aimed to evaluate t...

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Autores principales: Cordova, Ezequiel, Lespada, M. Ines, Cecchini, Diego, Nieto, Fabiola, Palonski, Susana, Badran, Mariana, Bernasconi, Silvina, Bacelar, Brenda, Morganti, Laura, Garibaldi, Franco, Bermejo, Veronica, Aguirre, Viviana, Badia, Marcela, Rodriguez, Claudia G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Published by Elsevier España, S.L.U. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9132791/
http://dx.doi.org/10.1016/j.vacune.2022.05.003
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author Cordova, Ezequiel
Lespada, M. Ines
Cecchini, Diego
Nieto, Fabiola
Palonski, Susana
Badran, Mariana
Bernasconi, Silvina
Bacelar, Brenda
Morganti, Laura
Garibaldi, Franco
Bermejo, Veronica
Aguirre, Viviana
Badia, Marcela
Rodriguez, Claudia G.
author_facet Cordova, Ezequiel
Lespada, M. Ines
Cecchini, Diego
Nieto, Fabiola
Palonski, Susana
Badran, Mariana
Bernasconi, Silvina
Bacelar, Brenda
Morganti, Laura
Garibaldi, Franco
Bermejo, Veronica
Aguirre, Viviana
Badia, Marcela
Rodriguez, Claudia G.
author_sort Cordova, Ezequiel
collection PubMed
description BACKGROUND: Vaccination for COVID-19 in healthcare workers (HCW) is essential to protect one of the populations most exposed to this disease. However, data on the humoral response rate to the vaccine and the factors associated with it in this population are limited. Therefore, we aimed to evaluate the antibody response against SARS-CoV-2 in HCWs with complete Sputnik V vaccine scheme and factors associated with an increased antibody response. MATERIAL AND METHODS: Prospective study to evaluate the anti-SARS-CoV-2 humoral response in HCWs vaccinated with two doses of the Sputnik V vaccine (April-July 2021). The assessment of anti-Spike IgG antibodies in plasma was performed using the COVIDAR IgG enzyme-linked immunosorbent assay. A logistic regression was performed to identify independent factors associated with a positive IgG serology test and an elevated antibody response. RESULTS: A total of 630 HCWs were enrolled. Median age (IQR): 47 years (35-56). Female sex: 462 (73.33%). Previous COVID-19: 158 (25%). The median interval time between vaccine doses was 3 (3-4) weeks. Positive serology was observed in 607 (96.35%) HCWs. In the multivariate analysis, a history of systemic reactogenicity was identified as an independent variable associated with a positive serology; and history of systemic reactogenicity, COVID-19, interval between doses ≥ 4 weeks and time to serology < 14 weeks were associated with an elevated antibody response. CONCLUSIONS: This study provides data on the humoral response to the Sputnik V vaccine in a real-life setting. These initial data can contribute to the development of future immunization strategies in HCWs.
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spelling pubmed-91327912022-05-26 Assessment of the humoral immunity induced by Sputnik V Covid-19 vaccine (GAM-COVID-VAC) in healthcare workers() Cordova, Ezequiel Lespada, M. Ines Cecchini, Diego Nieto, Fabiola Palonski, Susana Badran, Mariana Bernasconi, Silvina Bacelar, Brenda Morganti, Laura Garibaldi, Franco Bermejo, Veronica Aguirre, Viviana Badia, Marcela Rodriguez, Claudia G. Vacunas (English Edition) Original Article BACKGROUND: Vaccination for COVID-19 in healthcare workers (HCW) is essential to protect one of the populations most exposed to this disease. However, data on the humoral response rate to the vaccine and the factors associated with it in this population are limited. Therefore, we aimed to evaluate the antibody response against SARS-CoV-2 in HCWs with complete Sputnik V vaccine scheme and factors associated with an increased antibody response. MATERIAL AND METHODS: Prospective study to evaluate the anti-SARS-CoV-2 humoral response in HCWs vaccinated with two doses of the Sputnik V vaccine (April-July 2021). The assessment of anti-Spike IgG antibodies in plasma was performed using the COVIDAR IgG enzyme-linked immunosorbent assay. A logistic regression was performed to identify independent factors associated with a positive IgG serology test and an elevated antibody response. RESULTS: A total of 630 HCWs were enrolled. Median age (IQR): 47 years (35-56). Female sex: 462 (73.33%). Previous COVID-19: 158 (25%). The median interval time between vaccine doses was 3 (3-4) weeks. Positive serology was observed in 607 (96.35%) HCWs. In the multivariate analysis, a history of systemic reactogenicity was identified as an independent variable associated with a positive serology; and history of systemic reactogenicity, COVID-19, interval between doses ≥ 4 weeks and time to serology < 14 weeks were associated with an elevated antibody response. CONCLUSIONS: This study provides data on the humoral response to the Sputnik V vaccine in a real-life setting. These initial data can contribute to the development of future immunization strategies in HCWs. Published by Elsevier España, S.L.U. 2022-08 2022-05-26 /pmc/articles/PMC9132791/ http://dx.doi.org/10.1016/j.vacune.2022.05.003 Text en © 2022 Published by Elsevier España, S.L.U. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Original Article
Cordova, Ezequiel
Lespada, M. Ines
Cecchini, Diego
Nieto, Fabiola
Palonski, Susana
Badran, Mariana
Bernasconi, Silvina
Bacelar, Brenda
Morganti, Laura
Garibaldi, Franco
Bermejo, Veronica
Aguirre, Viviana
Badia, Marcela
Rodriguez, Claudia G.
Assessment of the humoral immunity induced by Sputnik V Covid-19 vaccine (GAM-COVID-VAC) in healthcare workers()
title Assessment of the humoral immunity induced by Sputnik V Covid-19 vaccine (GAM-COVID-VAC) in healthcare workers()
title_full Assessment of the humoral immunity induced by Sputnik V Covid-19 vaccine (GAM-COVID-VAC) in healthcare workers()
title_fullStr Assessment of the humoral immunity induced by Sputnik V Covid-19 vaccine (GAM-COVID-VAC) in healthcare workers()
title_full_unstemmed Assessment of the humoral immunity induced by Sputnik V Covid-19 vaccine (GAM-COVID-VAC) in healthcare workers()
title_short Assessment of the humoral immunity induced by Sputnik V Covid-19 vaccine (GAM-COVID-VAC) in healthcare workers()
title_sort assessment of the humoral immunity induced by sputnik v covid-19 vaccine (gam-covid-vac) in healthcare workers()
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9132791/
http://dx.doi.org/10.1016/j.vacune.2022.05.003
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