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Myocardial perfusion quantification with Rb-82 PET: good interobserver agreement of Carimas software on global, regional, and segmental levels

PURPOSE: To estimate the interobserver agreement of the Carimas software package (SP) on global, regional, and segmental levels for the most widely used myocardial perfusion PET tracer—Rb-82. MATERIALS AND METHODS: Rest and stress Rb-82 PET scans of 48 patients with suspected or known coronary arter...

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Autores principales: Nesterov, Sergey V., Deshayes, Emmanuel, Juarez-Orozco, Luis Eduardo, deKemp, Robert A., Sciagrà, Roberto, Malaspina, Simona, Settimo, Leonardo, Han, Chunlei, Ryzhkova, Darja V., Kostina, Irina S., Gwet, Kilem L., Prior, John O., Knuuti, Juhani M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Nature Singapore 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9132838/
https://www.ncbi.nlm.nih.gov/pubmed/35192160
http://dx.doi.org/10.1007/s12149-022-01729-5
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author Nesterov, Sergey V.
Deshayes, Emmanuel
Juarez-Orozco, Luis Eduardo
deKemp, Robert A.
Sciagrà, Roberto
Malaspina, Simona
Settimo, Leonardo
Han, Chunlei
Ryzhkova, Darja V.
Kostina, Irina S.
Gwet, Kilem L.
Prior, John O.
Knuuti, Juhani M.
author_facet Nesterov, Sergey V.
Deshayes, Emmanuel
Juarez-Orozco, Luis Eduardo
deKemp, Robert A.
Sciagrà, Roberto
Malaspina, Simona
Settimo, Leonardo
Han, Chunlei
Ryzhkova, Darja V.
Kostina, Irina S.
Gwet, Kilem L.
Prior, John O.
Knuuti, Juhani M.
author_sort Nesterov, Sergey V.
collection PubMed
description PURPOSE: To estimate the interobserver agreement of the Carimas software package (SP) on global, regional, and segmental levels for the most widely used myocardial perfusion PET tracer—Rb-82. MATERIALS AND METHODS: Rest and stress Rb-82 PET scans of 48 patients with suspected or known coronary artery disease (CAD) were analyzed in four centers using the Carimas SP. We considered values to agree if they simultaneously had an intraclass correlation coefficient (ICC) > 0.75 and a difference < 20% of the median across all observers. RESULTS: The median values on the segmental level were 1.08 mL/min/g for rest myocardial blood flow (MBF), 2.24 mL/min/g for stress MBF, and 2.17 for myocardial flow reserve (MFR). For the rest MBF and MFR, all the values at all the levels fulfilled were in excellent agreement. For stress MBF, at the global and regional levels, all the 24 comparisons showed excellent agreement. Only 1 out of 102 segmental comparisons (seg. 14) was over the adequate agreement limit—23.5% of the median value (ICC = 0.95). CONCLUSION: Interobserver agreement for Rb-82 PET myocardial perfusion quantification analyzed with Carimas is good at any LV segmentation level—global, regional, and segmental. It is good for all the estimates—rest MBF, stress MBF, and MFR.
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spelling pubmed-91328382022-05-27 Myocardial perfusion quantification with Rb-82 PET: good interobserver agreement of Carimas software on global, regional, and segmental levels Nesterov, Sergey V. Deshayes, Emmanuel Juarez-Orozco, Luis Eduardo deKemp, Robert A. Sciagrà, Roberto Malaspina, Simona Settimo, Leonardo Han, Chunlei Ryzhkova, Darja V. Kostina, Irina S. Gwet, Kilem L. Prior, John O. Knuuti, Juhani M. Ann Nucl Med Original Article PURPOSE: To estimate the interobserver agreement of the Carimas software package (SP) on global, regional, and segmental levels for the most widely used myocardial perfusion PET tracer—Rb-82. MATERIALS AND METHODS: Rest and stress Rb-82 PET scans of 48 patients with suspected or known coronary artery disease (CAD) were analyzed in four centers using the Carimas SP. We considered values to agree if they simultaneously had an intraclass correlation coefficient (ICC) > 0.75 and a difference < 20% of the median across all observers. RESULTS: The median values on the segmental level were 1.08 mL/min/g for rest myocardial blood flow (MBF), 2.24 mL/min/g for stress MBF, and 2.17 for myocardial flow reserve (MFR). For the rest MBF and MFR, all the values at all the levels fulfilled were in excellent agreement. For stress MBF, at the global and regional levels, all the 24 comparisons showed excellent agreement. Only 1 out of 102 segmental comparisons (seg. 14) was over the adequate agreement limit—23.5% of the median value (ICC = 0.95). CONCLUSION: Interobserver agreement for Rb-82 PET myocardial perfusion quantification analyzed with Carimas is good at any LV segmentation level—global, regional, and segmental. It is good for all the estimates—rest MBF, stress MBF, and MFR. Springer Nature Singapore 2022-02-22 2022 /pmc/articles/PMC9132838/ /pubmed/35192160 http://dx.doi.org/10.1007/s12149-022-01729-5 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Original Article
Nesterov, Sergey V.
Deshayes, Emmanuel
Juarez-Orozco, Luis Eduardo
deKemp, Robert A.
Sciagrà, Roberto
Malaspina, Simona
Settimo, Leonardo
Han, Chunlei
Ryzhkova, Darja V.
Kostina, Irina S.
Gwet, Kilem L.
Prior, John O.
Knuuti, Juhani M.
Myocardial perfusion quantification with Rb-82 PET: good interobserver agreement of Carimas software on global, regional, and segmental levels
title Myocardial perfusion quantification with Rb-82 PET: good interobserver agreement of Carimas software on global, regional, and segmental levels
title_full Myocardial perfusion quantification with Rb-82 PET: good interobserver agreement of Carimas software on global, regional, and segmental levels
title_fullStr Myocardial perfusion quantification with Rb-82 PET: good interobserver agreement of Carimas software on global, regional, and segmental levels
title_full_unstemmed Myocardial perfusion quantification with Rb-82 PET: good interobserver agreement of Carimas software on global, regional, and segmental levels
title_short Myocardial perfusion quantification with Rb-82 PET: good interobserver agreement of Carimas software on global, regional, and segmental levels
title_sort myocardial perfusion quantification with rb-82 pet: good interobserver agreement of carimas software on global, regional, and segmental levels
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9132838/
https://www.ncbi.nlm.nih.gov/pubmed/35192160
http://dx.doi.org/10.1007/s12149-022-01729-5
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