Healthcare services relaxing natural selection may contribute to increase of dementia incidence

Ageing and genetic traits can only explain the increasing dementia incidence partially. Advanced healthcare services allow dementia patients to survive natural selection and pass their genes onto the next generation. Country-specific estimates of dementia incidence rates (all ages and 15–49 years old), Biological State Index expressing reduced natural selection (I(s)), ageing indexed by life expectancy e((65)), GDP PPP and urbanization were obtained for analysing the global and regional correlations between reduced natural selection and dementia incidence with SPSS v. 27. Worldwide, I(s) significantly, but inversely, correlates with dementia incidence rates for both all ages and 15–49 years old in bivariate correlations. These relationships remain inversely correlated regardless of the competing contributing effects from ageing, GDP and urbanization in partial correlation model. Results of multiple linear regression (enter) have shown that I(s) is the significant predictor of dementia incidence among all ages and 15–49 years old. Subsequently, I(s) was selected as the variable having the greatest influence on dementia incidence in stepwise multiple linear regression. The I(s) correlated with dementia incidence more strongly in developed population groupings. Worldwide, reduced natural selection may be yet another significant contributor to dementia incidence with special regard to developed populations.