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Evolution and loss of ß-catenin and TCF-dependent axis specification in insects
Mechanisms and evolution of primary axis specification in insects are discussed in the context of the roles of ß-catenin and TCF in polarizing metazoan embryos. Three hypotheses are presented. First, insects with sequential segmentation and posterior growth use cell-autonomous mechanisms for establi...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9133022/ https://www.ncbi.nlm.nih.gov/pubmed/35104659 http://dx.doi.org/10.1016/j.cois.2022.100877 |
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author | Schmidt-Ott, Urs Yoon, Yoseop |
author_facet | Schmidt-Ott, Urs Yoon, Yoseop |
author_sort | Schmidt-Ott, Urs |
collection | PubMed |
description | Mechanisms and evolution of primary axis specification in insects are discussed in the context of the roles of ß-catenin and TCF in polarizing metazoan embryos. Three hypotheses are presented. First, insects with sequential segmentation and posterior growth use cell-autonomous mechanisms for establishing embryo polarity via the nuclear ratio of ß-catenin and TCF. Second, TCF homologs establish competence for anterior specification. Third, the evolution of simultaneous segmentation mechanisms, also known as long-germ development, resulted in primary axis specification mechanisms that are independent of ß-catenin but reliant on TCF, a condition that preceded the frequent replacement of anterior determinants in long germ insects. |
format | Online Article Text |
id | pubmed-9133022 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
record_format | MEDLINE/PubMed |
spelling | pubmed-91330222023-04-01 Evolution and loss of ß-catenin and TCF-dependent axis specification in insects Schmidt-Ott, Urs Yoon, Yoseop Curr Opin Insect Sci Article Mechanisms and evolution of primary axis specification in insects are discussed in the context of the roles of ß-catenin and TCF in polarizing metazoan embryos. Three hypotheses are presented. First, insects with sequential segmentation and posterior growth use cell-autonomous mechanisms for establishing embryo polarity via the nuclear ratio of ß-catenin and TCF. Second, TCF homologs establish competence for anterior specification. Third, the evolution of simultaneous segmentation mechanisms, also known as long-germ development, resulted in primary axis specification mechanisms that are independent of ß-catenin but reliant on TCF, a condition that preceded the frequent replacement of anterior determinants in long germ insects. 2022-04 2022-01-31 /pmc/articles/PMC9133022/ /pubmed/35104659 http://dx.doi.org/10.1016/j.cois.2022.100877 Text en https://creativecommons.org/licenses/by-nc-nd/4.0/This manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/ |
spellingShingle | Article Schmidt-Ott, Urs Yoon, Yoseop Evolution and loss of ß-catenin and TCF-dependent axis specification in insects |
title | Evolution and loss of ß-catenin and TCF-dependent axis specification in insects |
title_full | Evolution and loss of ß-catenin and TCF-dependent axis specification in insects |
title_fullStr | Evolution and loss of ß-catenin and TCF-dependent axis specification in insects |
title_full_unstemmed | Evolution and loss of ß-catenin and TCF-dependent axis specification in insects |
title_short | Evolution and loss of ß-catenin and TCF-dependent axis specification in insects |
title_sort | evolution and loss of ß-catenin and tcf-dependent axis specification in insects |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9133022/ https://www.ncbi.nlm.nih.gov/pubmed/35104659 http://dx.doi.org/10.1016/j.cois.2022.100877 |
work_keys_str_mv | AT schmidtotturs evolutionandlossofßcateninandtcfdependentaxisspecificationininsects AT yoonyoseop evolutionandlossofßcateninandtcfdependentaxisspecificationininsects |