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Molecular mechanism of the wake-promoting agent TAK-925

The OX(2) orexin receptor (OX(2)R) is a highly expressed G protein-coupled receptor (GPCR) in the brain that regulates wakefulness and circadian rhythms in humans. Antagonism of OX(2)R is a proven therapeutic strategy for insomnia drugs, and agonism of OX(2)R is a potentially powerful approach for n...

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Detalles Bibliográficos
Autores principales:	Yin, Jie, Kang, Yanyong, McGrath, Aaron P., Chapman, Karen, Sjodt, Megan, Kimura, Eiji, Okabe, Atsutoshi, Koike, Tatsuki, Miyanohana, Yuhei, Shimizu, Yuji, Rallabandi, Rameshu, Lian, Peng, Bai, Xiaochen, Flinspach, Mack, De Brabander, Jef K., Rosenbaum, Daniel M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9133036/ https://www.ncbi.nlm.nih.gov/pubmed/35614071 http://dx.doi.org/10.1038/s41467-022-30601-3

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