O-GlcNAc modification of leucyl-tRNA synthetase 1 integrates leucine and glucose availability to regulate mTORC1 and the metabolic fate of leucine

All living organisms have the ability to sense nutrient levels to coordinate cellular metabolism. Despite the importance of nutrient-sensing pathways that detect the levels of amino acids and glucose, how the availability of these two types of nutrients is integrated is unclear. Here, we show that g...

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Detalles Bibliográficos
Autores principales: Kim, Kibum, Yoo, Hee Chan, Kim, Byung Gyu, Kim, Sulhee, Sung, Yulseung, Yoon, Ina, Yu, Ya Chun, Park, Seung Joon, Kim, Jong Hyun, Myung, Kyungjae, Hwang, Kwang Yeon, Kim, Sunghoon, Han, Jung Min
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9133088/
https://www.ncbi.nlm.nih.gov/pubmed/35614056
http://dx.doi.org/10.1038/s41467-022-30696-8

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