Chondroitin sulfate proteoglycans prevent immune cell phenotypic conversion and inflammation resolution via TLR4 in rodent models of spinal cord injury

Chondroitin sulfate proteoglycans (CSPGs) act as potent inhibitors of axonal growth and neuroplasticity after spinal cord injury (SCI). Here we reveal that CSPGs also play a critical role in preventing inflammation resolution by blocking the conversion of pro-inflammatory immune cells to a pro-repai...

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Detalles Bibliográficos
Autores principales: Francos-Quijorna, Isaac, Sánchez-Petidier, Marina, Burnside, Emily R., Badea, Smaranda R., Torres-Espin, Abel, Marshall, Lucy, de Winter, Fred, Verhaagen, Joost, Moreno-Manzano, Victoria, Bradbury, Elizabeth J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9133109/
https://www.ncbi.nlm.nih.gov/pubmed/35614038
http://dx.doi.org/10.1038/s41467-022-30467-5

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