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The structural basis of Cdc7-Dbf4 kinase dependent targeting and phosphorylation of the MCM2-7 double hexamer

The controlled assembly of replication forks is critical for genome stability. The Dbf4-dependent Cdc7 kinase (DDK) initiates replisome assembly by phosphorylating the MCM2-7 replicative helicase at the N-terminal tails of Mcm2, Mcm4 and Mcm6. At present, it remains poorly understood how DDK docks o...

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Detalles Bibliográficos
Autores principales:	Saleh, Almutasem, Noguchi, Yasunori, Aramayo, Ricardo, Ivanova, Marina E., Stevens, Kathryn M., Montoya, Alex, Sunidhi, S., Carranza, Nicolas Lopez, Skwark, Marcin J., Speck, Christian
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9133112/ https://www.ncbi.nlm.nih.gov/pubmed/35614055 http://dx.doi.org/10.1038/s41467-022-30576-1

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