An Myh11 single lysine deletion causes aortic dissection by reducing aortic structural integrity and contractility

Pathogenic variants in myosin heavy chain (Myh11) cause familial thoracic aortic aneurysms and dissections (FTAAD). However, the underlying pathological mechanisms remain unclear because of a lack of animal models. In this study, we established a mouse model with Myh11 K1256del, the pathogenic varia...

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Detalles Bibliográficos
Autores principales: Negishi, Keita, Aizawa, Kenichi, Shindo, Takayuki, Suzuki, Toru, Sakurai, Takayuki, Saito, Yuichiro, Miyakawa, Takuya, Tanokura, Masaru, Kataoka, Yosky, Maeda, Mitsuyo, Tomida, Shota, Morita, Hiroyuki, Takeda, Norifumi, Komuro, Issei, Kario, Kazuomi, Nagai, Ryozo, Imai, Yasushi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9133116/
https://www.ncbi.nlm.nih.gov/pubmed/35614093
http://dx.doi.org/10.1038/s41598-022-12418-8

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