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Exosome-Derived Non-Coding RNAs in the Tumor Microenvironment of Colorectal Cancer: Possible Functions, Mechanisms and Clinical Applications

Colorectal cancer (CRC) is the second leading cause of cancer death and the third most prevalent malignancy. Colorectal tumors exchange information with the surrounding environment and influence each other, which collectively constitutes the tumor microenvironment (TME) of CRC. Many studies have sho...

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Autores principales: Chen, Xian, Jia, Mengmeng, Ji, Jing, Zhao, Zhiying, Zhao, Yanjie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9133322/
https://www.ncbi.nlm.nih.gov/pubmed/35646623
http://dx.doi.org/10.3389/fonc.2022.887532
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author Chen, Xian
Jia, Mengmeng
Ji, Jing
Zhao, Zhiying
Zhao, Yanjie
author_facet Chen, Xian
Jia, Mengmeng
Ji, Jing
Zhao, Zhiying
Zhao, Yanjie
author_sort Chen, Xian
collection PubMed
description Colorectal cancer (CRC) is the second leading cause of cancer death and the third most prevalent malignancy. Colorectal tumors exchange information with the surrounding environment and influence each other, which collectively constitutes the tumor microenvironment (TME) of CRC. Many studies have shown that exosome-derived non-coding RNAs (ncRNAs) play important roles in various pathophysiological processes by regulating the TME of CRC. This review summarizes recent findings on the fundamental roles of exosomal ncRNAs in angiogenesis, vascular permeability, tumor immunity, tumor metabolism and drug resistance. Certainly, the in-depth understanding of exosomal ncRNAs will provide comprehensive insights into the clinical application of these molecules against CRC.
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spelling pubmed-91333222022-05-27 Exosome-Derived Non-Coding RNAs in the Tumor Microenvironment of Colorectal Cancer: Possible Functions, Mechanisms and Clinical Applications Chen, Xian Jia, Mengmeng Ji, Jing Zhao, Zhiying Zhao, Yanjie Front Oncol Oncology Colorectal cancer (CRC) is the second leading cause of cancer death and the third most prevalent malignancy. Colorectal tumors exchange information with the surrounding environment and influence each other, which collectively constitutes the tumor microenvironment (TME) of CRC. Many studies have shown that exosome-derived non-coding RNAs (ncRNAs) play important roles in various pathophysiological processes by regulating the TME of CRC. This review summarizes recent findings on the fundamental roles of exosomal ncRNAs in angiogenesis, vascular permeability, tumor immunity, tumor metabolism and drug resistance. Certainly, the in-depth understanding of exosomal ncRNAs will provide comprehensive insights into the clinical application of these molecules against CRC. Frontiers Media S.A. 2022-05-12 /pmc/articles/PMC9133322/ /pubmed/35646623 http://dx.doi.org/10.3389/fonc.2022.887532 Text en Copyright © 2022 Chen, Jia, Ji, Zhao and Zhao https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Chen, Xian
Jia, Mengmeng
Ji, Jing
Zhao, Zhiying
Zhao, Yanjie
Exosome-Derived Non-Coding RNAs in the Tumor Microenvironment of Colorectal Cancer: Possible Functions, Mechanisms and Clinical Applications
title Exosome-Derived Non-Coding RNAs in the Tumor Microenvironment of Colorectal Cancer: Possible Functions, Mechanisms and Clinical Applications
title_full Exosome-Derived Non-Coding RNAs in the Tumor Microenvironment of Colorectal Cancer: Possible Functions, Mechanisms and Clinical Applications
title_fullStr Exosome-Derived Non-Coding RNAs in the Tumor Microenvironment of Colorectal Cancer: Possible Functions, Mechanisms and Clinical Applications
title_full_unstemmed Exosome-Derived Non-Coding RNAs in the Tumor Microenvironment of Colorectal Cancer: Possible Functions, Mechanisms and Clinical Applications
title_short Exosome-Derived Non-Coding RNAs in the Tumor Microenvironment of Colorectal Cancer: Possible Functions, Mechanisms and Clinical Applications
title_sort exosome-derived non-coding rnas in the tumor microenvironment of colorectal cancer: possible functions, mechanisms and clinical applications
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9133322/
https://www.ncbi.nlm.nih.gov/pubmed/35646623
http://dx.doi.org/10.3389/fonc.2022.887532
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