Pneumococcal Surface Proteins as Virulence Factors, Immunogens, and Conserved Vaccine Targets

Streptococcus pneumoniae is an opportunistic pathogen that causes over 1 million deaths annually despite the availability of several multivalent pneumococcal conjugate vaccines (PCVs). Due to the limitations surrounding PCVs along with an evolutionary rise in antibiotic-resistant and unencapsulated...

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Detalles Bibliográficos
Autores principales: Aceil, Javid, Avci, Fikri Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Cellular and Infection Microbiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9133333/
https://www.ncbi.nlm.nih.gov/pubmed/35646747
http://dx.doi.org/10.3389/fcimb.2022.832254
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author Aceil, Javid
Avci, Fikri Y.
author_facet Aceil, Javid
Avci, Fikri Y.
author_sort Aceil, Javid
collection PubMed
description Streptococcus pneumoniae is an opportunistic pathogen that causes over 1 million deaths annually despite the availability of several multivalent pneumococcal conjugate vaccines (PCVs). Due to the limitations surrounding PCVs along with an evolutionary rise in antibiotic-resistant and unencapsulated strains, conserved immunogenic proteins as vaccine targets continue to be an important field of study for pneumococcal disease prevention. In this review, we provide an overview of multiple classes of conserved surface proteins that have been studied for their contribution to pneumococcal virulence. Furthermore, we discuss the immune responses observed in response to these proteins and their promise as vaccine targets.
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spelling pubmed-91333332022-05-27 Pneumococcal Surface Proteins as Virulence Factors, Immunogens, and Conserved Vaccine Targets Aceil, Javid Avci, Fikri Y. Front Cell Infect Microbiol Cellular and Infection Microbiology Streptococcus pneumoniae is an opportunistic pathogen that causes over 1 million deaths annually despite the availability of several multivalent pneumococcal conjugate vaccines (PCVs). Due to the limitations surrounding PCVs along with an evolutionary rise in antibiotic-resistant and unencapsulated strains, conserved immunogenic proteins as vaccine targets continue to be an important field of study for pneumococcal disease prevention. In this review, we provide an overview of multiple classes of conserved surface proteins that have been studied for their contribution to pneumococcal virulence. Furthermore, we discuss the immune responses observed in response to these proteins and their promise as vaccine targets. Frontiers Media S.A. 2022-05-12 /pmc/articles/PMC9133333/ /pubmed/35646747 http://dx.doi.org/10.3389/fcimb.2022.832254 Text en Copyright © 2022 Aceil and Avci https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cellular and Infection Microbiology
Aceil, Javid
Avci, Fikri Y.
Pneumococcal Surface Proteins as Virulence Factors, Immunogens, and Conserved Vaccine Targets
title Pneumococcal Surface Proteins as Virulence Factors, Immunogens, and Conserved Vaccine Targets
title_full Pneumococcal Surface Proteins as Virulence Factors, Immunogens, and Conserved Vaccine Targets
title_fullStr Pneumococcal Surface Proteins as Virulence Factors, Immunogens, and Conserved Vaccine Targets
title_full_unstemmed Pneumococcal Surface Proteins as Virulence Factors, Immunogens, and Conserved Vaccine Targets
title_short Pneumococcal Surface Proteins as Virulence Factors, Immunogens, and Conserved Vaccine Targets
title_sort pneumococcal surface proteins as virulence factors, immunogens, and conserved vaccine targets
topic Cellular and Infection Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9133333/
https://www.ncbi.nlm.nih.gov/pubmed/35646747
http://dx.doi.org/10.3389/fcimb.2022.832254
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