White Matter Alterations in Depressive Disorder

Depressive disorder is the most prevalent affective disorder today. Depressive disorder has been linked to changes in the white matter. White matter changes in depressive disorder could be a result of impaired cerebral blood flow (CBF) and CBF self-regulation, impaired blood-brain barrier function,...

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Autores principales: He, Enling, Liu, Min, Gong, Sizhu, Fu, Xiyao, Han, Yue, Deng, Fang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9133348/
https://www.ncbi.nlm.nih.gov/pubmed/35634314
http://dx.doi.org/10.3389/fimmu.2022.826812
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author He, Enling
Liu, Min
Gong, Sizhu
Fu, Xiyao
Han, Yue
Deng, Fang
author_facet He, Enling
Liu, Min
Gong, Sizhu
Fu, Xiyao
Han, Yue
Deng, Fang
author_sort He, Enling
collection PubMed
description Depressive disorder is the most prevalent affective disorder today. Depressive disorder has been linked to changes in the white matter. White matter changes in depressive disorder could be a result of impaired cerebral blood flow (CBF) and CBF self-regulation, impaired blood-brain barrier function, inflammatory factors, genes and environmental factors. Additionally, white matter changes in patients with depression are associated with clinical variables such as differential diagnosis, severity, treatment effect, and efficacy assessment. This review discusses the characteristics, possible mechanisms, clinical relevance, and potential treatment of white matter alterations caused by depressive disorders.
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spelling pubmed-91333482022-05-27 White Matter Alterations in Depressive Disorder He, Enling Liu, Min Gong, Sizhu Fu, Xiyao Han, Yue Deng, Fang Front Immunol Immunology Depressive disorder is the most prevalent affective disorder today. Depressive disorder has been linked to changes in the white matter. White matter changes in depressive disorder could be a result of impaired cerebral blood flow (CBF) and CBF self-regulation, impaired blood-brain barrier function, inflammatory factors, genes and environmental factors. Additionally, white matter changes in patients with depression are associated with clinical variables such as differential diagnosis, severity, treatment effect, and efficacy assessment. This review discusses the characteristics, possible mechanisms, clinical relevance, and potential treatment of white matter alterations caused by depressive disorders. Frontiers Media S.A. 2022-05-12 /pmc/articles/PMC9133348/ /pubmed/35634314 http://dx.doi.org/10.3389/fimmu.2022.826812 Text en Copyright © 2022 He, Liu, Gong, Fu, Han and Deng https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
He, Enling
Liu, Min
Gong, Sizhu
Fu, Xiyao
Han, Yue
Deng, Fang
White Matter Alterations in Depressive Disorder
title White Matter Alterations in Depressive Disorder
title_full White Matter Alterations in Depressive Disorder
title_fullStr White Matter Alterations in Depressive Disorder
title_full_unstemmed White Matter Alterations in Depressive Disorder
title_short White Matter Alterations in Depressive Disorder
title_sort white matter alterations in depressive disorder
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9133348/
https://www.ncbi.nlm.nih.gov/pubmed/35634314
http://dx.doi.org/10.3389/fimmu.2022.826812
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