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Distinct phenotypic states and spatial distribution of CD8(+) T cell clonotypes in human brain metastases

Metastatic disease in the brain is difficult to control and predicts poor prognosis. Here, we analyze human brain metastases and demonstrate their robust infiltration by CD8(+) T cell subsets with distinct antigen specificities, phenotypic states, and spatial localization within the tumor microenvir...

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Detalles Bibliográficos
Autores principales:	Sudmeier, Lisa J., Hoang, Kimberly B., Nduom, Edjah K., Wieland, Andreas, Neill, Stewart G., Schniederjan, Matthew J., Ramalingam, Suresh S., Olson, Jeffrey J., Ahmed, Rafi, Hudson, William H.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9133402/ https://www.ncbi.nlm.nih.gov/pubmed/35584630 http://dx.doi.org/10.1016/j.xcrm.2022.100620

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