CD70 CAR T cells in AML: Form follows function

Using a multimodal approach toward developing a new CD70-targeted Chimeric antigen receptor (CAR) T cell in acute myeloid leukemia, Leick et al.(1) report on their synergetic strategy, which incorporates both CAR T cell construct modifications with enhancement of leukemia antigen expression to impro...

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Detalles Bibliográficos
Autores principales: Mirazee, Justin, Shah, Nirali N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Spotlight
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9133448/
https://www.ncbi.nlm.nih.gov/pubmed/35584621
http://dx.doi.org/10.1016/j.xcrm.2022.100639
Descripción
Sumario:Using a multimodal approach toward developing a new CD70-targeted Chimeric antigen receptor (CAR) T cell in acute myeloid leukemia, Leick et al.(1) report on their synergetic strategy, which incorporates both CAR T cell construct modifications with enhancement of leukemia antigen expression to improve CAR T cell functionality.

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