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Broad and ultra-potent cross-clade neutralization of HIV-1 by a vaccine-induced CD4 binding site bovine antibody

Human immunodeficiency virus type 1 (HIV-1) vaccination of cows has elicited broadly neutralizing antibodies (bNAbs). In this study, monoclonal antibodies (mAbs) are isolated from a clade A (KNH1144 and BG505) vaccinated cow using a heterologous clade B antigen (AD8). CD4 binding site (CD4bs) bNAb (...

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Detalles Bibliográficos
Autores principales:	Heydarchi, Behnaz, Fong, Danielle S., Gao, Hongmei, Salazar-Quiroz, Natalia A., Edwards, Jack M., Gonelli, Christopher A., Grimley, Samantha, Aktepe, Turgut E., Mackenzie, Charlene, Wales, William J., van Gils, Marit J., Cupo, Albert, Rouiller, Isabelle, Gooley, Paul R., Moore, John P., Sanders, Rogier W., Montefiori, David, Sethi, Ashish, Purcell, Damian F.J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9133467/ https://www.ncbi.nlm.nih.gov/pubmed/35584627 http://dx.doi.org/10.1016/j.xcrm.2022.100635

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