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Transcriptional profiling of macrophages in situ in metastatic melanoma reveals localization-dependent phenotypes and function

Modulation of immune function at the tumor site could improve patient outcomes. Here, we analyze patient samples of metastatic melanoma, a tumor responsive to T cell-based therapies, and find that tumor-infiltrating T cells are primarily juxtaposed to CD14(+) monocytes/macrophages rather than melano...

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Detalles Bibliográficos
Autores principales:	Martinek, Jan, Lin, Jianan, Kim, Kyung In, Wang, Victor G., Wu, Te-Chia, Chiorazzi, Michael, Boruchov, Hannah, Gulati, Ananya, Seeniraj, Shamreethaa, Sun, Lili, Marches, Florentina, Robson, Paul, Rongvaux, Anthony, Flavell, Richard A., George, Joshy, Chuang, Jeffrey H., Banchereau, Jacques, Palucka, Karolina
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9133468/ https://www.ncbi.nlm.nih.gov/pubmed/35584631 http://dx.doi.org/10.1016/j.xcrm.2022.100621

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