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Application of Physiologically Based Pharmacokinetic Modeling in Preclinical Studies: A Feasible Strategy to Practice the Principles of 3Rs

Pharmacokinetic characterization plays a vital role in drug discovery and development. Although involving numerous laboratory animals with error-prone, labor-intensive, and time-consuming procedures, pharmacokinetic profiling is still irreplaceable in preclinical studies. With physiologically based...

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Detalles Bibliográficos
Autores principales:	Yuan, Yawen, He, Qingfeng, Zhang, Shunguo, Li, Min, Tang, Zhijia, Zhu, Xiao, Jiao, Zheng, Cai, Weimin, Xiang, Xiaoqiang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9133488/ https://www.ncbi.nlm.nih.gov/pubmed/35645843 http://dx.doi.org/10.3389/fphar.2022.895556

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