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The Auxiliary Role of Heparin in Bone Regeneration and its Application in Bone Substitute Materials
Bone regeneration in large segmental defects depends on the action of osteoblasts and the ingrowth of new blood vessels. Therefore, it is important to promote the release of osteogenic/angiogenic growth factors. Since the discovery of heparin, its anticoagulant, anti-inflammatory, and anticancer fun...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9133562/ https://www.ncbi.nlm.nih.gov/pubmed/35646879 http://dx.doi.org/10.3389/fbioe.2022.837172 |
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author | Wang, Jing Xiao, Lan Wang, Weiqun Zhang, Dingmei Ma, Yaping Zhang, Yi Wang, Xin |
author_facet | Wang, Jing Xiao, Lan Wang, Weiqun Zhang, Dingmei Ma, Yaping Zhang, Yi Wang, Xin |
author_sort | Wang, Jing |
collection | PubMed |
description | Bone regeneration in large segmental defects depends on the action of osteoblasts and the ingrowth of new blood vessels. Therefore, it is important to promote the release of osteogenic/angiogenic growth factors. Since the discovery of heparin, its anticoagulant, anti-inflammatory, and anticancer functions have been extensively studied for over a century. Although the application of heparin is widely used in the orthopedic field, its auxiliary effect on bone regeneration is yet to be unveiled. Specifically, approximately one-third of the transforming growth factor (TGF) superfamily is bound to heparin and heparan sulfate, among which TGF-β1, TGF-β2, and bone morphogenetic protein (BMP) are the most common growth factors used. In addition, heparin can also improve the delivery and retention of BMP-2 in vivo promoting the healing of large bone defects at hyper physiological doses. In blood vessel formation, heparin still plays an integral part of fracture healing by cooperating with the platelet-derived growth factor (PDGF). Importantly, since heparin binds to growth factors and release components in nanomaterials, it can significantly facilitate the controlled release and retention of growth factors [such as fibroblast growth factor (FGF), BMP, and PDGF] in vivo. Consequently, the knowledge of scaffolds or delivery systems composed of heparin and different biomaterials (including organic, inorganic, metal, and natural polymers) is vital for material-guided bone regeneration research. This study systematically reviews the structural properties and auxiliary functions of heparin, with an emphasis on bone regeneration and its application in biomaterials under physiological conditions. |
format | Online Article Text |
id | pubmed-9133562 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-91335622022-05-27 The Auxiliary Role of Heparin in Bone Regeneration and its Application in Bone Substitute Materials Wang, Jing Xiao, Lan Wang, Weiqun Zhang, Dingmei Ma, Yaping Zhang, Yi Wang, Xin Front Bioeng Biotechnol Bioengineering and Biotechnology Bone regeneration in large segmental defects depends on the action of osteoblasts and the ingrowth of new blood vessels. Therefore, it is important to promote the release of osteogenic/angiogenic growth factors. Since the discovery of heparin, its anticoagulant, anti-inflammatory, and anticancer functions have been extensively studied for over a century. Although the application of heparin is widely used in the orthopedic field, its auxiliary effect on bone regeneration is yet to be unveiled. Specifically, approximately one-third of the transforming growth factor (TGF) superfamily is bound to heparin and heparan sulfate, among which TGF-β1, TGF-β2, and bone morphogenetic protein (BMP) are the most common growth factors used. In addition, heparin can also improve the delivery and retention of BMP-2 in vivo promoting the healing of large bone defects at hyper physiological doses. In blood vessel formation, heparin still plays an integral part of fracture healing by cooperating with the platelet-derived growth factor (PDGF). Importantly, since heparin binds to growth factors and release components in nanomaterials, it can significantly facilitate the controlled release and retention of growth factors [such as fibroblast growth factor (FGF), BMP, and PDGF] in vivo. Consequently, the knowledge of scaffolds or delivery systems composed of heparin and different biomaterials (including organic, inorganic, metal, and natural polymers) is vital for material-guided bone regeneration research. This study systematically reviews the structural properties and auxiliary functions of heparin, with an emphasis on bone regeneration and its application in biomaterials under physiological conditions. Frontiers Media S.A. 2022-05-12 /pmc/articles/PMC9133562/ /pubmed/35646879 http://dx.doi.org/10.3389/fbioe.2022.837172 Text en Copyright © 2022 Wang, Xiao, Wang, Zhang, Ma, Zhang and Wang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Bioengineering and Biotechnology Wang, Jing Xiao, Lan Wang, Weiqun Zhang, Dingmei Ma, Yaping Zhang, Yi Wang, Xin The Auxiliary Role of Heparin in Bone Regeneration and its Application in Bone Substitute Materials |
title | The Auxiliary Role of Heparin in Bone Regeneration and its Application in Bone Substitute Materials |
title_full | The Auxiliary Role of Heparin in Bone Regeneration and its Application in Bone Substitute Materials |
title_fullStr | The Auxiliary Role of Heparin in Bone Regeneration and its Application in Bone Substitute Materials |
title_full_unstemmed | The Auxiliary Role of Heparin in Bone Regeneration and its Application in Bone Substitute Materials |
title_short | The Auxiliary Role of Heparin in Bone Regeneration and its Application in Bone Substitute Materials |
title_sort | auxiliary role of heparin in bone regeneration and its application in bone substitute materials |
topic | Bioengineering and Biotechnology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9133562/ https://www.ncbi.nlm.nih.gov/pubmed/35646879 http://dx.doi.org/10.3389/fbioe.2022.837172 |
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