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The Auxiliary Role of Heparin in Bone Regeneration and its Application in Bone Substitute Materials

Bone regeneration in large segmental defects depends on the action of osteoblasts and the ingrowth of new blood vessels. Therefore, it is important to promote the release of osteogenic/angiogenic growth factors. Since the discovery of heparin, its anticoagulant, anti-inflammatory, and anticancer fun...

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Autores principales: Wang, Jing, Xiao, Lan, Wang, Weiqun, Zhang, Dingmei, Ma, Yaping, Zhang, Yi, Wang, Xin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9133562/
https://www.ncbi.nlm.nih.gov/pubmed/35646879
http://dx.doi.org/10.3389/fbioe.2022.837172
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author Wang, Jing
Xiao, Lan
Wang, Weiqun
Zhang, Dingmei
Ma, Yaping
Zhang, Yi
Wang, Xin
author_facet Wang, Jing
Xiao, Lan
Wang, Weiqun
Zhang, Dingmei
Ma, Yaping
Zhang, Yi
Wang, Xin
author_sort Wang, Jing
collection PubMed
description Bone regeneration in large segmental defects depends on the action of osteoblasts and the ingrowth of new blood vessels. Therefore, it is important to promote the release of osteogenic/angiogenic growth factors. Since the discovery of heparin, its anticoagulant, anti-inflammatory, and anticancer functions have been extensively studied for over a century. Although the application of heparin is widely used in the orthopedic field, its auxiliary effect on bone regeneration is yet to be unveiled. Specifically, approximately one-third of the transforming growth factor (TGF) superfamily is bound to heparin and heparan sulfate, among which TGF-β1, TGF-β2, and bone morphogenetic protein (BMP) are the most common growth factors used. In addition, heparin can also improve the delivery and retention of BMP-2 in vivo promoting the healing of large bone defects at hyper physiological doses. In blood vessel formation, heparin still plays an integral part of fracture healing by cooperating with the platelet-derived growth factor (PDGF). Importantly, since heparin binds to growth factors and release components in nanomaterials, it can significantly facilitate the controlled release and retention of growth factors [such as fibroblast growth factor (FGF), BMP, and PDGF] in vivo. Consequently, the knowledge of scaffolds or delivery systems composed of heparin and different biomaterials (including organic, inorganic, metal, and natural polymers) is vital for material-guided bone regeneration research. This study systematically reviews the structural properties and auxiliary functions of heparin, with an emphasis on bone regeneration and its application in biomaterials under physiological conditions.
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spelling pubmed-91335622022-05-27 The Auxiliary Role of Heparin in Bone Regeneration and its Application in Bone Substitute Materials Wang, Jing Xiao, Lan Wang, Weiqun Zhang, Dingmei Ma, Yaping Zhang, Yi Wang, Xin Front Bioeng Biotechnol Bioengineering and Biotechnology Bone regeneration in large segmental defects depends on the action of osteoblasts and the ingrowth of new blood vessels. Therefore, it is important to promote the release of osteogenic/angiogenic growth factors. Since the discovery of heparin, its anticoagulant, anti-inflammatory, and anticancer functions have been extensively studied for over a century. Although the application of heparin is widely used in the orthopedic field, its auxiliary effect on bone regeneration is yet to be unveiled. Specifically, approximately one-third of the transforming growth factor (TGF) superfamily is bound to heparin and heparan sulfate, among which TGF-β1, TGF-β2, and bone morphogenetic protein (BMP) are the most common growth factors used. In addition, heparin can also improve the delivery and retention of BMP-2 in vivo promoting the healing of large bone defects at hyper physiological doses. In blood vessel formation, heparin still plays an integral part of fracture healing by cooperating with the platelet-derived growth factor (PDGF). Importantly, since heparin binds to growth factors and release components in nanomaterials, it can significantly facilitate the controlled release and retention of growth factors [such as fibroblast growth factor (FGF), BMP, and PDGF] in vivo. Consequently, the knowledge of scaffolds or delivery systems composed of heparin and different biomaterials (including organic, inorganic, metal, and natural polymers) is vital for material-guided bone regeneration research. This study systematically reviews the structural properties and auxiliary functions of heparin, with an emphasis on bone regeneration and its application in biomaterials under physiological conditions. Frontiers Media S.A. 2022-05-12 /pmc/articles/PMC9133562/ /pubmed/35646879 http://dx.doi.org/10.3389/fbioe.2022.837172 Text en Copyright © 2022 Wang, Xiao, Wang, Zhang, Ma, Zhang and Wang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Bioengineering and Biotechnology
Wang, Jing
Xiao, Lan
Wang, Weiqun
Zhang, Dingmei
Ma, Yaping
Zhang, Yi
Wang, Xin
The Auxiliary Role of Heparin in Bone Regeneration and its Application in Bone Substitute Materials
title The Auxiliary Role of Heparin in Bone Regeneration and its Application in Bone Substitute Materials
title_full The Auxiliary Role of Heparin in Bone Regeneration and its Application in Bone Substitute Materials
title_fullStr The Auxiliary Role of Heparin in Bone Regeneration and its Application in Bone Substitute Materials
title_full_unstemmed The Auxiliary Role of Heparin in Bone Regeneration and its Application in Bone Substitute Materials
title_short The Auxiliary Role of Heparin in Bone Regeneration and its Application in Bone Substitute Materials
title_sort auxiliary role of heparin in bone regeneration and its application in bone substitute materials
topic Bioengineering and Biotechnology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9133562/
https://www.ncbi.nlm.nih.gov/pubmed/35646879
http://dx.doi.org/10.3389/fbioe.2022.837172
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