Generating functional cells through enhanced interspecies chimerism with human pluripotent stem cells

Obtaining functional human cells through interspecies chimerism with human pluripotent stem cells (hPSCs) remains unsuccessful due to its extremely low efficiency. Here, we show that hPSCs failed to differentiate and contribute teratoma in the presence of mouse PSCs (mPSCs), while MYCN, a pro-growth...

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Detalles Bibliográficos
Autores principales: Zhu, Yanling, Zhang, Zhishuai, Fan, Nana, Huang, Ke, Li, Hao, Gu, Jiaming, Zhang, Quanjun, Ouyang, Zhen, Zhang, Tian, Tang, Jun, Zhang, Yanqi, Suo, Yangyang, Lai, Chengdan, Wang, Jiaowei, Wang, Junwei, Shan, Yongli, Wang, Mingquan, Chen, Qianyu, Zhou, Tiancheng, Lai, Liangxue, Pan, Guangjin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9133581/
https://www.ncbi.nlm.nih.gov/pubmed/35427483
http://dx.doi.org/10.1016/j.stemcr.2022.03.009

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