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Complex dynamics and control analysis of an epidemic model with non-monotone incidence and saturated treatment

In this manuscript, we consider an epidemic model having constant recruitment of susceptible individuals with non-monotone disease transmission rate and saturated-type treatment rate. Two types of disease control strategies are taken here, namely vaccination for susceptible individuals and treatment...

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Autores principales: Saha, Pritam, Ghosh, Uttam
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9133617/
https://www.ncbi.nlm.nih.gov/pubmed/35637768
http://dx.doi.org/10.1007/s40435-022-00969-7
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author Saha, Pritam
Ghosh, Uttam
author_facet Saha, Pritam
Ghosh, Uttam
author_sort Saha, Pritam
collection PubMed
description In this manuscript, we consider an epidemic model having constant recruitment of susceptible individuals with non-monotone disease transmission rate and saturated-type treatment rate. Two types of disease control strategies are taken here, namely vaccination for susceptible individuals and treatment for infected individuals to minimize the impact of the disease. We study local as well as global stability analysis of the disease-free equilibrium point and also endemic equilibrium point based on the values of basic reproduction number [Formula: see text] . Therefore, disease eradicates from the population if basic reproduction number less than unity and disease persists in the population if basic reproduction number greater than unity. We use center manifold theorem to study the dynamical behavior of the disease-free equilibrium point for [Formula: see text] . We investigate different bifurcations such as transcritical bifurcation, backward bifurcation, saddle-node bifurcation, Hopf bifurcation and Bogdanov–Takens bifurcation of co-dimension 2. The biological significance of all types of bifurcations are described. Some numerical simulations are performed to check the reliability of our theoretical approach. Sensitivity analysis is performed to identify the influential model parameters which have most impact on the basic reproduction number of the proposed model. To control or eradicate the influence of the emerging disease, we need to control the most sensitive model parameters using necessary preventive measures. We study optimal control problem using Pontryagin’s maximum principle. Finally using efficiency analysis, we determine most effective control strategy among applied controls.
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spelling pubmed-91336172022-05-26 Complex dynamics and control analysis of an epidemic model with non-monotone incidence and saturated treatment Saha, Pritam Ghosh, Uttam Int J Dyn Control Article In this manuscript, we consider an epidemic model having constant recruitment of susceptible individuals with non-monotone disease transmission rate and saturated-type treatment rate. Two types of disease control strategies are taken here, namely vaccination for susceptible individuals and treatment for infected individuals to minimize the impact of the disease. We study local as well as global stability analysis of the disease-free equilibrium point and also endemic equilibrium point based on the values of basic reproduction number [Formula: see text] . Therefore, disease eradicates from the population if basic reproduction number less than unity and disease persists in the population if basic reproduction number greater than unity. We use center manifold theorem to study the dynamical behavior of the disease-free equilibrium point for [Formula: see text] . We investigate different bifurcations such as transcritical bifurcation, backward bifurcation, saddle-node bifurcation, Hopf bifurcation and Bogdanov–Takens bifurcation of co-dimension 2. The biological significance of all types of bifurcations are described. Some numerical simulations are performed to check the reliability of our theoretical approach. Sensitivity analysis is performed to identify the influential model parameters which have most impact on the basic reproduction number of the proposed model. To control or eradicate the influence of the emerging disease, we need to control the most sensitive model parameters using necessary preventive measures. We study optimal control problem using Pontryagin’s maximum principle. Finally using efficiency analysis, we determine most effective control strategy among applied controls. Springer Berlin Heidelberg 2022-05-26 2023 /pmc/articles/PMC9133617/ /pubmed/35637768 http://dx.doi.org/10.1007/s40435-022-00969-7 Text en © The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2022 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Article
Saha, Pritam
Ghosh, Uttam
Complex dynamics and control analysis of an epidemic model with non-monotone incidence and saturated treatment
title Complex dynamics and control analysis of an epidemic model with non-monotone incidence and saturated treatment
title_full Complex dynamics and control analysis of an epidemic model with non-monotone incidence and saturated treatment
title_fullStr Complex dynamics and control analysis of an epidemic model with non-monotone incidence and saturated treatment
title_full_unstemmed Complex dynamics and control analysis of an epidemic model with non-monotone incidence and saturated treatment
title_short Complex dynamics and control analysis of an epidemic model with non-monotone incidence and saturated treatment
title_sort complex dynamics and control analysis of an epidemic model with non-monotone incidence and saturated treatment
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9133617/
https://www.ncbi.nlm.nih.gov/pubmed/35637768
http://dx.doi.org/10.1007/s40435-022-00969-7
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