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Phenotypic Characterization of Idiopathic Epilepsy in Border Collies

The prevalence of idiopathic epilepsy (IE) within the Border Collie (BC) dog breed is high. The aim of this retrospective study was to describe the phenotype of BCs with IE and assess correlations between phenotypic variables and owner-provided quality-of-life (QoL) scores. Data of BCs diagnosed wit...

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Autores principales: Santifort, Koen M., Bertijn, Elise, Bhatti, Sofie F. M., Leegwater, Peter, Fischer, Andrea, Mandigers, Paul J. J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9133619/
https://www.ncbi.nlm.nih.gov/pubmed/35647099
http://dx.doi.org/10.3389/fvets.2022.880318
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author Santifort, Koen M.
Bertijn, Elise
Bhatti, Sofie F. M.
Leegwater, Peter
Fischer, Andrea
Mandigers, Paul J. J.
author_facet Santifort, Koen M.
Bertijn, Elise
Bhatti, Sofie F. M.
Leegwater, Peter
Fischer, Andrea
Mandigers, Paul J. J.
author_sort Santifort, Koen M.
collection PubMed
description The prevalence of idiopathic epilepsy (IE) within the Border Collie (BC) dog breed is high. The aim of this retrospective study was to describe the phenotype of BCs with IE and assess correlations between phenotypic variables and owner-provided quality-of-life (QoL) scores. Data of BCs diagnosed with IE during the period of five consecutive years were retrospectively analyzed. All the dogs were presented at least once to a veterinary neurology specialist at one of three veterinary referral hospitals and most were under the continued medical care of that specialist. Owners were requested to complete a standardized online questionnaire including quality-of-life (QoL) scoring questions. Data of a total of 116 BC dogs were included for analysis. The median age at onset of the first epileptic seizure (ES) was 33.5 months (6–188). A total of 34/86 (40%) of medically treated dogs received 1 antiseizure medication (ASM) and 52/86 (60%) received ≥2 ASMs. Phenobarbital was the most commonly employed ASM, used in 70/86 of treated dogs (81%). Four or more side effects were observed in 20/86 (23%) of treated dogs. Age at onset of first ES was significantly lower for dogs having experienced cluster seizures (CSs), status epilepticus (SE), or both (median 27 months) vs. dogs that had not experienced CS or SE (median 43 months). The QoL of BC with IE was scored with a median score of 7 out of 10. Owners scored their dog's QoL to have declined by a median of 30% during the course of life with IE with 39% (37/95) of owners scoring their dog's QoL to have declined by ≥50%. This study confirms the association of age at onset of first ES with the severity of epilepsy (e.g., presence of CS and/or SE) and further characterizes the phenotype of IE in BC dogs. QoL of BC can be heavily impacted by IE.
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spelling pubmed-91336192022-05-27 Phenotypic Characterization of Idiopathic Epilepsy in Border Collies Santifort, Koen M. Bertijn, Elise Bhatti, Sofie F. M. Leegwater, Peter Fischer, Andrea Mandigers, Paul J. J. Front Vet Sci Veterinary Science The prevalence of idiopathic epilepsy (IE) within the Border Collie (BC) dog breed is high. The aim of this retrospective study was to describe the phenotype of BCs with IE and assess correlations between phenotypic variables and owner-provided quality-of-life (QoL) scores. Data of BCs diagnosed with IE during the period of five consecutive years were retrospectively analyzed. All the dogs were presented at least once to a veterinary neurology specialist at one of three veterinary referral hospitals and most were under the continued medical care of that specialist. Owners were requested to complete a standardized online questionnaire including quality-of-life (QoL) scoring questions. Data of a total of 116 BC dogs were included for analysis. The median age at onset of the first epileptic seizure (ES) was 33.5 months (6–188). A total of 34/86 (40%) of medically treated dogs received 1 antiseizure medication (ASM) and 52/86 (60%) received ≥2 ASMs. Phenobarbital was the most commonly employed ASM, used in 70/86 of treated dogs (81%). Four or more side effects were observed in 20/86 (23%) of treated dogs. Age at onset of first ES was significantly lower for dogs having experienced cluster seizures (CSs), status epilepticus (SE), or both (median 27 months) vs. dogs that had not experienced CS or SE (median 43 months). The QoL of BC with IE was scored with a median score of 7 out of 10. Owners scored their dog's QoL to have declined by a median of 30% during the course of life with IE with 39% (37/95) of owners scoring their dog's QoL to have declined by ≥50%. This study confirms the association of age at onset of first ES with the severity of epilepsy (e.g., presence of CS and/or SE) and further characterizes the phenotype of IE in BC dogs. QoL of BC can be heavily impacted by IE. Frontiers Media S.A. 2022-05-12 /pmc/articles/PMC9133619/ /pubmed/35647099 http://dx.doi.org/10.3389/fvets.2022.880318 Text en Copyright © 2022 Santifort, Bertijn, Bhatti, Leegwater, Fischer and Mandigers. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Veterinary Science
Santifort, Koen M.
Bertijn, Elise
Bhatti, Sofie F. M.
Leegwater, Peter
Fischer, Andrea
Mandigers, Paul J. J.
Phenotypic Characterization of Idiopathic Epilepsy in Border Collies
title Phenotypic Characterization of Idiopathic Epilepsy in Border Collies
title_full Phenotypic Characterization of Idiopathic Epilepsy in Border Collies
title_fullStr Phenotypic Characterization of Idiopathic Epilepsy in Border Collies
title_full_unstemmed Phenotypic Characterization of Idiopathic Epilepsy in Border Collies
title_short Phenotypic Characterization of Idiopathic Epilepsy in Border Collies
title_sort phenotypic characterization of idiopathic epilepsy in border collies
topic Veterinary Science
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9133619/
https://www.ncbi.nlm.nih.gov/pubmed/35647099
http://dx.doi.org/10.3389/fvets.2022.880318
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