Activation of the adhesion G protein–coupled receptor GPR133 by antibodies targeting its N-terminus

We recently demonstrated that GPR133 (ADGRD1), an adhesion G protein–coupled receptor involved in raising cytosolic cAMP levels, is necessary for growth of glioblastoma (GBM) and is de novo expressed in GBM relative to normal brain tissue. Our previous work suggested that dissociation of autoproteol...

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Detalles Bibliográficos
Autores principales: Stephan, Gabriele, Frenster, Joshua D., Liebscher, Ines, Placantonakis, Dimitris G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9133650/
https://www.ncbi.nlm.nih.gov/pubmed/35447113
http://dx.doi.org/10.1016/j.jbc.2022.101949

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