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Viral and bacterial co-infection in hospitalised children with refractory Mycoplasma pneumoniae pneumonia
To investigate the impact of viral and bacterial co-infection in hospitalised children with Mycoplasma pneumoniae pneumonia (RMPP). Retrospective analysis of 396 children with RMPP in our hospital admitted between 1 January 2011 and 31 December 2016 was performed. Nasal aspirate samples were collect...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cambridge University Press
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9133674/ https://www.ncbi.nlm.nih.gov/pubmed/29970200 http://dx.doi.org/10.1017/S0950268818000778 |
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author | Zhang, Xinxing Chen, Zhengrong Gu, Wenjing Ji, Wei Wang, Yuqing Hao, Chuangli He, Yanyu Huang, Li Wang, Meijuan Shao, Xuejun Yan, Yongdong |
author_facet | Zhang, Xinxing Chen, Zhengrong Gu, Wenjing Ji, Wei Wang, Yuqing Hao, Chuangli He, Yanyu Huang, Li Wang, Meijuan Shao, Xuejun Yan, Yongdong |
author_sort | Zhang, Xinxing |
collection | PubMed |
description | To investigate the impact of viral and bacterial co-infection in hospitalised children with Mycoplasma pneumoniae pneumonia (RMPP). Retrospective analysis of 396 children with RMPP in our hospital admitted between 1 January 2011 and 31 December 2016 was performed. Nasal aspirate samples were collected for pathogen detection and clinical data were collected. We analysed clinical characteristics, lung imaging characteristics and pathogenic species among these children. Of the 396 RMPP cases, 107 (27.02%) had co-infection with other pathogen, with Streptococcus pneumoniae, Haemophilus influenzae and Staphylococcus aureus being the most common bacteria of infection and human bocavirus (HBoV), human rhinovirus, respiratory syncytial virus being the most common viruses of infection. Children with co-infection were younger than that with single infection (P = 0.010). Children with both virus and bacteria co-infection had been the youngest (P = 0.040). Children with co-infection had a longer fever process, higher leukocyte count, higher C-reactive protein compared with single infection (P < 0.05). Children with co-infection had a higher percentage of pnemothorax and diffuse large area of inflammation in chest X-ray manifestation compared with children with single infection (P < 0.05). S. pneumonia and HBoV was the leading cause of co-infection in RMPP. Co-infections led to more disease severity in children with RMPP compared with single infections. |
format | Online Article Text |
id | pubmed-9133674 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Cambridge University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-91336742022-06-17 Viral and bacterial co-infection in hospitalised children with refractory Mycoplasma pneumoniae pneumonia Zhang, Xinxing Chen, Zhengrong Gu, Wenjing Ji, Wei Wang, Yuqing Hao, Chuangli He, Yanyu Huang, Li Wang, Meijuan Shao, Xuejun Yan, Yongdong Epidemiol Infect Original Paper To investigate the impact of viral and bacterial co-infection in hospitalised children with Mycoplasma pneumoniae pneumonia (RMPP). Retrospective analysis of 396 children with RMPP in our hospital admitted between 1 January 2011 and 31 December 2016 was performed. Nasal aspirate samples were collected for pathogen detection and clinical data were collected. We analysed clinical characteristics, lung imaging characteristics and pathogenic species among these children. Of the 396 RMPP cases, 107 (27.02%) had co-infection with other pathogen, with Streptococcus pneumoniae, Haemophilus influenzae and Staphylococcus aureus being the most common bacteria of infection and human bocavirus (HBoV), human rhinovirus, respiratory syncytial virus being the most common viruses of infection. Children with co-infection were younger than that with single infection (P = 0.010). Children with both virus and bacteria co-infection had been the youngest (P = 0.040). Children with co-infection had a longer fever process, higher leukocyte count, higher C-reactive protein compared with single infection (P < 0.05). Children with co-infection had a higher percentage of pnemothorax and diffuse large area of inflammation in chest X-ray manifestation compared with children with single infection (P < 0.05). S. pneumonia and HBoV was the leading cause of co-infection in RMPP. Co-infections led to more disease severity in children with RMPP compared with single infections. Cambridge University Press 2018-08 2018-07-04 /pmc/articles/PMC9133674/ /pubmed/29970200 http://dx.doi.org/10.1017/S0950268818000778 Text en © Cambridge University Press 2018 https://creativecommons.org/licenses/by/4.0/This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Paper Zhang, Xinxing Chen, Zhengrong Gu, Wenjing Ji, Wei Wang, Yuqing Hao, Chuangli He, Yanyu Huang, Li Wang, Meijuan Shao, Xuejun Yan, Yongdong Viral and bacterial co-infection in hospitalised children with refractory Mycoplasma pneumoniae pneumonia |
title | Viral and bacterial co-infection in hospitalised children with refractory Mycoplasma pneumoniae pneumonia |
title_full | Viral and bacterial co-infection in hospitalised children with refractory Mycoplasma pneumoniae pneumonia |
title_fullStr | Viral and bacterial co-infection in hospitalised children with refractory Mycoplasma pneumoniae pneumonia |
title_full_unstemmed | Viral and bacterial co-infection in hospitalised children with refractory Mycoplasma pneumoniae pneumonia |
title_short | Viral and bacterial co-infection in hospitalised children with refractory Mycoplasma pneumoniae pneumonia |
title_sort | viral and bacterial co-infection in hospitalised children with refractory mycoplasma pneumoniae pneumonia |
topic | Original Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9133674/ https://www.ncbi.nlm.nih.gov/pubmed/29970200 http://dx.doi.org/10.1017/S0950268818000778 |
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