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The Methanol Extract of Polygonatum odoratum Ameliorates Colitis by Improving Intestinal Short-Chain Fatty Acids and Gas Production to Regulate Microbiota Dysbiosis in Mice
The potential impacts of methanol extract from Polygonatum odoratum on (YZM) colonic histopathology, gut gas production, short-chain fatty acids (SCFAs), and intestinal microbiota composition were evaluated with dextran sulfate sodium (DSS)-induced colitis mice in this study. These results indicated...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9133717/ https://www.ncbi.nlm.nih.gov/pubmed/35634366 http://dx.doi.org/10.3389/fnut.2022.899421 |
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author | Ye, Xuewei Pi, Xionge Zheng, Wenxin Cen, Yingxin Ni, Jiahui Xu, Langyu Wu, Kefei Liu, Wei Li, Lanjuan |
author_facet | Ye, Xuewei Pi, Xionge Zheng, Wenxin Cen, Yingxin Ni, Jiahui Xu, Langyu Wu, Kefei Liu, Wei Li, Lanjuan |
author_sort | Ye, Xuewei |
collection | PubMed |
description | The potential impacts of methanol extract from Polygonatum odoratum on (YZM) colonic histopathology, gut gas production, short-chain fatty acids (SCFAs), and intestinal microbiota composition were evaluated with dextran sulfate sodium (DSS)-induced colitis mice in this study. These results indicated that YZM increased colon length and ameliorated colonic histopathology in DSS-induced colitis mice. Moreover, YZM administration reversed intestinal microbiota compositions leading to the inhibition of H(2)S-related bacteria (e.g., Desulfovibrionaceae) and the lower level of H(2)S and higher contents of SCFA-related bacteria (e.g., Muribaculaceae). Taken together, the effects of methanol extract from Polygonatum odoratum are studied to provide new enlightenment and clues for its application as a functional food and clinical drug. Our study first revealed the relationship between intestinal gas production and key bacteria in ulcerative colitis. |
format | Online Article Text |
id | pubmed-9133717 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-91337172022-05-27 The Methanol Extract of Polygonatum odoratum Ameliorates Colitis by Improving Intestinal Short-Chain Fatty Acids and Gas Production to Regulate Microbiota Dysbiosis in Mice Ye, Xuewei Pi, Xionge Zheng, Wenxin Cen, Yingxin Ni, Jiahui Xu, Langyu Wu, Kefei Liu, Wei Li, Lanjuan Front Nutr Nutrition The potential impacts of methanol extract from Polygonatum odoratum on (YZM) colonic histopathology, gut gas production, short-chain fatty acids (SCFAs), and intestinal microbiota composition were evaluated with dextran sulfate sodium (DSS)-induced colitis mice in this study. These results indicated that YZM increased colon length and ameliorated colonic histopathology in DSS-induced colitis mice. Moreover, YZM administration reversed intestinal microbiota compositions leading to the inhibition of H(2)S-related bacteria (e.g., Desulfovibrionaceae) and the lower level of H(2)S and higher contents of SCFA-related bacteria (e.g., Muribaculaceae). Taken together, the effects of methanol extract from Polygonatum odoratum are studied to provide new enlightenment and clues for its application as a functional food and clinical drug. Our study first revealed the relationship between intestinal gas production and key bacteria in ulcerative colitis. Frontiers Media S.A. 2022-05-12 /pmc/articles/PMC9133717/ /pubmed/35634366 http://dx.doi.org/10.3389/fnut.2022.899421 Text en Copyright © 2022 Ye, Pi, Zheng, Cen, Ni, Xu, Wu, Liu and Li. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Nutrition Ye, Xuewei Pi, Xionge Zheng, Wenxin Cen, Yingxin Ni, Jiahui Xu, Langyu Wu, Kefei Liu, Wei Li, Lanjuan The Methanol Extract of Polygonatum odoratum Ameliorates Colitis by Improving Intestinal Short-Chain Fatty Acids and Gas Production to Regulate Microbiota Dysbiosis in Mice |
title | The Methanol Extract of Polygonatum odoratum Ameliorates Colitis by Improving Intestinal Short-Chain Fatty Acids and Gas Production to Regulate Microbiota Dysbiosis in Mice |
title_full | The Methanol Extract of Polygonatum odoratum Ameliorates Colitis by Improving Intestinal Short-Chain Fatty Acids and Gas Production to Regulate Microbiota Dysbiosis in Mice |
title_fullStr | The Methanol Extract of Polygonatum odoratum Ameliorates Colitis by Improving Intestinal Short-Chain Fatty Acids and Gas Production to Regulate Microbiota Dysbiosis in Mice |
title_full_unstemmed | The Methanol Extract of Polygonatum odoratum Ameliorates Colitis by Improving Intestinal Short-Chain Fatty Acids and Gas Production to Regulate Microbiota Dysbiosis in Mice |
title_short | The Methanol Extract of Polygonatum odoratum Ameliorates Colitis by Improving Intestinal Short-Chain Fatty Acids and Gas Production to Regulate Microbiota Dysbiosis in Mice |
title_sort | methanol extract of polygonatum odoratum ameliorates colitis by improving intestinal short-chain fatty acids and gas production to regulate microbiota dysbiosis in mice |
topic | Nutrition |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9133717/ https://www.ncbi.nlm.nih.gov/pubmed/35634366 http://dx.doi.org/10.3389/fnut.2022.899421 |
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